关键词: C-erbB-2, Bmi-1, PTEN, 基因, 大肠癌, 免疫组化

Abstract: Objective To study expression of C-erbB-2, Bmi-1 and PTEN gene in colorectal carcinoma and its clinical significance. Methods 50 cases of colorectal carcinoma tissues and 50 cases of adjacent normalcolorectal mucosa were detected by immunohistochemical method, and the expression of C-erbB-2, Bmi-1 and PTEN gene in the study of the correlations and three genes were examined. Results (1) The expression of C-erbB-2, Bmi-1 gene in colorectal cancer tissues were significantly higher than the expression in normal colorectal tissues the expression of PTEN gene in colorectal carcinoma was significantly lower than the expression in normal colorectal tissues, the difference was statistically significant. (2) C-erbB-2, Bmi-1 gene in colorectal cancer and lymph node metastasis, degree of differentiation, depth of invasion, Ducks stage were positively correlated, and the incidence of colorectal cancer, the development and biological behavior had a role. While PTEN gene in colorectal cancer and lymph node metastasis, degree of differentiation, depth of invasion, Ducks staging were negatively related with colorectal cancer, the occurrence, development and biological behavior of inhibitory effect. (3) There was a correlation between C-erbB-2, Bmi-1 and PTEN genes in 3 colorectal cancer tissues, where C-erbB-2 and Bmi-1 genes in the development of colorectal cancer was related to the occurrence and development process. C-erbB-2 and PTEN genes of colorectal carcinoma was negatively correlated. Bmi-1 and PTEN gene in colorectal cancer development was negatively correlated. Conclusion C-erbB-2, Bmi-1 and PTEN gene in the occurrence play a role in the development of colorectal cancer, combined detection may be a prognostic marker and targeted therapy.

Key words: C-erbB-2, Bmi-1, PTEN, gene, colorectal cancer, immunohistochemistry