血管拟态在乳腺癌中的研究进展

doi:10.3969/j.issn.1674-490X.2022.02.003

摘要/Abstract

摘要： 血管拟态是一种特殊的血管生成模式,其管样结构由肿瘤细胞而非传统的内皮细胞构成,为肿瘤的生长、侵袭和转移提供营养。近年来,人们发现血管拟态与多种恶性肿瘤的预后、侵袭、转移和耐药性有关。目前普遍认为血管拟态和血管生成依赖于一些共同的机制。而且也有人认为血管拟态的形成是导致抗血管生成药物产生耐药性的原因之一。现对目前对乳腺癌中血管拟态形成的机制,包括相关的信号通路以及肿瘤干细胞、上皮间质化和抗血管生成治疗等研究成果做一综述,并且将对血管拟态作为乳腺癌治疗靶点的意义以及未来的发展方向进行展望。

关键词: 血管拟态, 乳腺癌, 肿瘤干细胞, 上皮间质化, 抗血管生成治疗

Abstract: Vasculogenic mimicry is a special model of angiogenesis. This structure is composed of tumor cells instead of traditional endothelial cells, and provides nutrition for tumor growth, invasion and metastasis. In recent years, it has been found that vasculogenic mimicry is related to the prognosis, invasion, metastasis and drug resistance of many kinds of malignant tumors. It is generally believed that vasculogenic mimicry and angiogenesis depend on some common mechanisms. And some people believe that the formation of vasculogenic mimicry is one of the reasons leading to the development of resistance to anti-angiogenic drugs. The mechanism of vasculogenic mimicry in breast cancer, including related signaling pathways, as well as tumor stem cells, epithelial mesenchymal and anti angiogenesis therapy, are reviewed. The significance and future direction of vasculogenic mimicry as a therapeutic target for breast cancer will be prospected.

Key words: vasculogenic mimicry, breast cancer, cancer stem cells, epithelial-mesenchymal transition, antiangiogenic therapy

中图分类号:

位亚利,孙珵珵,王晓春. 血管拟态在乳腺癌中的研究进展[J]. 医学研究与教育, 2022, 39(2): 16-23.

WEI Yali,SUN Chengcheng,WANG Xiaochun. Advances on vasculogenic mimicry in breast cancer[J]. Journal of Hebei Medical College for Continuing Education, 2022, 39(2): 16-23.

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