miRNA在高磷诱导的血管钙化中的作用

doi:10.3969/j.issn.1674-490X.2022.05.001

医学研究与教育 ›› 2022, Vol. 39 ›› Issue (5): 1-6.DOI: 10.3969/j.issn.1674-490X.2022.05.001

• 基础医学 • 下一篇

miRNA在高磷诱导的血管钙化中的作用

贾娟¹,梁思¹,陈恒利¹,王红杰^1,2,3

1.河北大学附属医院, 河北保定 071000;
2.河北大学基础医学院, 河北保定 071000;
3.河北省慢性肾脏病骨骼代谢生理学重点实验室, 河北保定 071000

收稿日期:2022-08-22 出版日期:2022-10-25 发布日期:2022-10-25
通讯作者: 王红杰(1968—),女,河北保定人,主任医师,教授,博士,博士生导师,主要从事麻醉与复苏的临床及基础研究。E-mail: hongjiew68@163.com
作者简介:贾娟(1989—),女,河北保定人,在读博士,主要从事慢性肾脏病、高磷血症和血管钙化研究。 E-mail: jiajuan90@163.com 通信作者:王红杰(1968—),女,河北保定人,主任医师,教授,博士,博士生导师,主要从事麻醉与复苏的临床及基础研究。 E-mail: hongjiew68@163.com
基金资助:
保定市科技支撑计划项目(17ZF245)

The role of microRNA in high phosphorus induced vascular calcification

JIA Juan¹, LIANG Si¹, CHEN Hengli¹, WANG Hongjie^1,2,3

1.Affiliated Hospital of Hebei University, Baoding 071000, China; 2.College of Basic Medicine, Hebei University, Baoding 071000, China; 3.Key Laboratory of Bone Metabolism and Physiology of Chronic Kidney Disease of Hebei Province, Baoding 071000, China

Received:2022-08-22 Online:2022-10-25 Published:2022-10-25

摘要/Abstract

摘要： 血管钙化是慢性肾脏病患者心血管疾病发生及发展的病理基础。高磷血症是导致慢性肾脏病患者发生血管钙化的最主要危险因素。在高磷状态下,微小RNA(microRNA, miRNA)通过转录后负性调控靶细胞表达促进或抑制钙化因子而起到调控血管钙化的作用。因此,鉴定高磷状态下miRNA的异常产生有助于识别表观遗传变化,这些变化可以作为预防和治疗高磷血症诱导的血管钙化的靶点。现综述目前发现的与高磷诱导血管钙化发生有关的miRNA及其作用机制。

关键词: 微小RNA, 高磷, 血管钙化

Abstract: Vascular calcification is the pathological basis of the occurrence and development of cardiovascular disease in patients with chronic kidney disease. Hyperphosphatemia is the most important risk factor for vascular calcification in patients with chronic kidney disease. It has been found that under high phosphorus conditions, microRNA(miRNA)plays a role in regulating vascular calcification by negatively regulating the expression of target cells after transcription to promote or inhibit calcification factors. Therefore, identifying the abnormal production of miRNA under hyperphosphatemia is helpful to identify epigenetic changes, which can be used as a target for the prevention and treatment of hyperphosphatemia induced vascular calcification. In this review, miRNA and their mechanisms related to high phosphate induced vascular calcification are reviewed.

Key words: microRNA, high phosphorus, vascular calcification

中图分类号:

贾娟, 梁思, 陈恒利, 王红杰. miRNA在高磷诱导的血管钙化中的作用[J]. 医学研究与教育, 2022, 39(5): 1-6.

JIA Juan, LIANG Si, CHEN Hengli, WANG Hongjie. The role of microRNA in high phosphorus induced vascular calcification[J]. Journal of Hebei Medical College for Continuing Education, 2022, 39(5): 1-6.

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miRNA在高磷诱导的血管钙化中的作用

The role of microRNA in high phosphorus induced vascular calcification

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