从肠道菌群的角度分析衰弱在冠心病中的作用

doi:10.3969/j.issn.1674-490X.2024.03.003

摘要/Abstract

摘要： 冠心病是老年人最常见的死亡原因。衰弱在老年患者中的发病率明显增加。衰弱评估能够很好预测老年冠心病患者预后。但是,衰弱导致冠心病不良预后的机制目前并不十分明确。近年来,由于基因测序技术的进步,肠道菌群与老年衰弱的相关性也更加明确,肠道菌群可能在衰弱合并冠心病的患者中发挥重要作用。现通过分析肠道菌群与衰弱的关系,说明肠道菌群对衰弱合并冠心病患者发生、发展的重要作用。通过早期调节衰弱患者肠道菌群,进而达到预防不良心血管事件发生,从而为临床对冠心病患者的二级预防提供理论依据。

关键词: 冠心病, 衰弱, 肠道微生物组, 衰弱评估

Abstract: Coronary heart disease is the most common cause of death in the elderly. The incidence of frailty in elderly patients is significantly increased. Frailty assessment can well predict the prognosis of elderly patients with coronary heart disease. However, the mechanism of frailty leading to poor prognosis of coronary heart disease is not very clear. Studies have shown that intestinal flora may play an important role in patients with frailty and coronary heart disease. In recent years, due to the advancement of gene sequencing technology, the correlation between intestinal flora and frailty in the elderly has become clearer. The main purposes of this review are to explain the important role of intestinal flora in the occurrence and development of patients with frailty and coronary heart disease by analyzing the relationship between intestinal flora and frailty through early intervention of intestinal flora in patients with frailty to achieve the purpose of preventing adverse cardiovascular events and in order to provide a theoretical basis for clinical secondary prevention of patients with coronary heart disease.

Key words: coronary heart disease, frailty, intestinal microbiome, frailty assessment

中图分类号:

冯荣,鲁佳慧,李赞,李朝洋,李亚芹,崔红根. 从肠道菌群的角度分析衰弱在冠心病中的作用[J]. 医学研究与教育, 2024, 41(3): 18-24.

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