Effects of Xuefu Zhuyu Decoction on the expression of matrix metalloproteianse-9 and tissue metalloproteinase inhibitor-1 in atherosclerotic rats

doi:10.3969/j.issn.1674-490X.2013.05.003

Abstract

Abstract: Objective To investgate the effects of Xuefu Zhuyu Decoction on the expression of matrix metalloproteianse-9 and tissue metalloproteinase inhibitor-1 in aorta of atheroselerotic rats. Methods 30 SD rats were randomly divided into the control group model group and Xuefu Zhuyu Decoction group(each n=15), the rats of the control group were given normal diet, that of the model group were given a high fat diet, the rats of Xuefu Zhuyu Decoction group were given a high fat diet and given treatment drugs. After 12 weeks, all rats were killed and expression of MMP-9 and TIMP-1 in atheroselerotic plaque were detected by using immunohistochemistry assay. Results The MMP-9 expression decreased signiifcantly(P<0.05), and TIMP-1 expression increased significantly(P<0.05) in the Xuefu Zhuyu Decoction compared with that of the model group. Conclusion The Xuefu Zhuyu Decoction can decrease the expression of MMP-9 and increase the expression of TIMP-1, it can attenuate atherosclerotic development in rats.

Key words: Xuefu Zhuyu Decoction, atherosclerosis, matrix metalloproteianse-9, tissue metalloproteinase inhibitor-1

CLC Number:

R363

HUANG Wei,DONG Chao. Effects of Xuefu Zhuyu Decoction on the expression of matrix metalloproteianse-9 and tissue metalloproteinase inhibitor-1 in atherosclerotic rats[J]. Medical Reserch and Education, 2013, 30(5): 8-12.

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