Changes and clinical significance of carotid atherosclerosis and soluble intercellular adhesion molecules-1 in cerebral infarction patients with obstructive sleep apnea-hypopnea syndrome

doi:10.3969/j.issn.1674-490X.2015.04.001

Abstract

Abstract: Objective To investigate the relationship between carotid atherosclerosis and soluble intercellular adhesion molecules-1（sICAM-1）in middle-aged and young patients of cerebral infarction（CI）with obstructive sleep apnea-hypopnea syndrome(OSAHS) . Methods 68 middle-aged and young patients of CI were divided into two groups according to whether with OSAHS，CI group （35）and CI with OSAHS group （33） . All patients were checked carotid artery through color doppler ultrasound and record intima-media thickness (IMT) .The serum sICAM-1 of all patients were assayed by means of double antibody sandwich method and enzyme linked immunosorbent assay (ELISA). Results The IMT in middle-aged and young patients of CI with OSAHS were (1.333±0.185)mm，significantly higher than that of CI group (P<0.01), the serum levels of sICAM-1 were also significantly higher than that of CI group. IMT were correlated positively with sICAM-1(P<0.01). Conclusion The IMT of carotid artery in middle-aged and young patients of CI with OSAHS are probably correlated with sICAM-1.

Key words: cerebral infarction, sleep apnea-hypopnea, intercellular adhesion molecules

ZHAO Huixin, ZHANG Xinghong, LI Weibin, WANG Chuhan, DI Weiying. Changes and clinical significance of carotid atherosclerosis and soluble intercellular adhesion molecules-1 in cerebral infarction patients with obstructive sleep apnea-hypopnea syndrome[J]. Medical Reserch and Education, 2015, 32(4): 1-4.

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