doi:10.3969/j.issn.1674-490X.2019.01.003

Abstract

Abstract: Objective To investigate the correlation between serum bilirubin and homocysteine(Hcy)and the stability of carotid atherosclerotic plaques in patients with acute cerebral infarction. Methods 192 patients with acute ischemic stroke were selected to collect peripheral venous blood on the second early morning in the hospital. The serum bilirubin were detected by chemical oxidation and Hcy were detected by fluorescence polarization immunoassay. Two groups of carotid artery intima-media thickness(IMT)were measured by IU-22 color Doppler ultrasonography, and the correlation of serum bilirubin and Hcy levels with carotid atherosclerotic plaques in patients with acute cerebral infarction was analyzed. Results The serum bilirubin(especially direct bilirubin)in vulnerable plaque group was significantly lower than that of the stable plaque group(P <0.05), and the level of Hcy in vulnerable plaque group was significantly higher than that of the stable plaque group(P < 0.05). Conclusion The stability of carotid atherosclerotic plaque in patients with acute cerebral infarction may be negatively correlated with the level of blood Hcy, and is positively correlated with the level of serum total bilirubin and direct bilirubin to some degree.

Key words: acute cerebral infarction, bilirubin, homocysteine, carotid atherosclerotic plaques, stability

CLC Number:

R743.3

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