Study on the mechanism of apoptosis and angiogenesis in promoting the development of fibrosis

doi:10.3969/j.issn.1674-490X.2015.04.009

Abstract

Abstract: Fibrosis is usually seen in the liver, lung, heart, kidney and skin. Apoptosis has been identified as a potential initiator and propagator of fibrosis. The occurrence of apoptosis has an important effect on fibroblast phenotype and collagen metabolism. Simultaneously, fibrosis in these models is generally preceded by robust angiogenesis and vascular regression, suggesting that the vascular apoptotic burden may be important to fibrotic outcomes. Angiogenesis inhibitors in the experimental research has shown good curative effect against liver fibrosis. This review considers the emerging evidence that angiogenesis or vascular regression contributes to fibrosis and identifies initial vascular outgrowth or vascular apoptotic cell presence as possible regulators of fibrosis.

Key words: apoptosis, angiogenesis, fibrosis

QU Penghuan, SHI Jianhong. Study on the mechanism of apoptosis and angiogenesis in promoting the development of fibrosis[J]. Medical Reserch and Education, 2015, 32(4): 33-37.

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