Abstract: Objective To study the clinical characteristics and the comprehensive diagnosis and treatment of gastroesophageal reflux larynspasm(GERL). Methods GERL patients with characteristics of laryngeal spasm by symptoms questionnaire selected from January 2010 to June 2016 were admitted continuous hospitalization; had excellent response to PPI, antireflux radiofrequency or fundoplication after gastroscopy, manometry and 24 hours pH examination; without laryngeal spasm episodes in follow-up of more than 12 months after antireflux therapy.The gastroesophageal reflux disease(GERD)symptom spectrum, characteristics of larynspasm attack, examination results, and response to antireflux treatment of the GERL patients were statistically analyzed. Results A total of 64 patients with GERL were included in the study, with an average age of 48.9 years. 71.9% of the patients had typical symptoms of GERD such as acid reflux and heartburn, 75% had other extraesophageal reflux symptoms such as cough and asthma. 35.9% of the patients complained regurgitation could cause choking cough and the following larynspasm, 73.4% reported of increased larynspasm episodes after meal, irritating food intake, over eating, or alcohol consumption, and 42.2% complained larynspasm was prone to occure in supine position during sleep. The detecting rates of pathological acid reflux and esophagitis by 24 h pH monitoring and gastroscopy were 53.1% and 48.6%, respectively. 37.5% of the patients had good response, 51.6% had partial response, and 10.9% had poor response to PPI therapy. 84.4% of the patients failed to stop or had no resopse to PPI converted to radiofrequency or fundoplication, and good results were achieved. Conclusion Larynspasm could one of the extraesophageal reflux manifestations of GERD, larynspasm could be combined with typical symptoms and/or extraesophageal symptoms of GERD. Part of the patients’ larynspasm onset is associated with reflux symptoms, diet and body position, which is helpful for the diagnosis of GERL. GERL usually responds well to antireflux therapy such as PPI, radiofrequency and fundoplication.

Key words: laryngospasm, gastroesophageal reflux disease, proton pump inhibitor, radiofrequence, fundoplication