Abstract: Cardiovascular disease(CVD)is the leading cause of death in our country.However,its pathogenesis is still unclear.Studies have found that RhoA/ROCK signaling pathway is closely related to the occurrence and development of hypertension,coronary heart disease,heart failure,arrhythmia and other diseases.ROCK inhibitors also provide new ideas for the treatment of cardiovascular diseases.The research on RhoA/ROCK signaling pathway in cardiovascular diseases is reviewed.

Key words: RhoA/ROCK signaling pathway, cardiovascular disease, Rho associated kinase inhibitors

CLC Number: