Efficacy and safety analysis of ultrapulsed fractional CO2 laser combined with photorejuvenation in the treatment of facial atrophic acne scars

doi:10.3969/j.issn.1674-490X.2026.03.005

Abstract

Abstract: Objective To evaluate the clinical efficacy and safety of ultrapulsed fractional CO₂ laser combined with photorejuvenation for the treatment of facial atrophic acne scars.Methods Sixty patients with acne scars from the Department of Dermatology, Affiliated Hospital of Hebei University were randomly assigned to a CO₂ laser group and a combination treatment group, with 30 patients in each. The CO₂ laser group received ultrapulsed fractional CO₂ laser treatment once every 3 months for a total of 5 sessions. The combination treatment group received the same ultrapulsed fractional CO₂ laser treatment, and one month after each laser session, photorejuvenation treatment was added, completing a total of 5 combined treatment cycles.Results The marked improvement rate in the combination group(70.00%)was significantly higher than that in the CO₂ laser group(36.67%)(P=0.011), and the combination therapy demonstrated superior pain relief(P=0.007). Subgroup analysis showed that the combination approach led to greater improvement of icepick and rolling scars compared with the control group. The total effective rate exceeded 90% in both groups, and no serious adverse events were observed.Conclusion Ultrapulsed fractional CO₂ laser combined with photorejuvenation is a safe and effective treatment strategy, particularly suitable for icepick and rolling types of atrophic acne scars.

Key words: ultrapulse fractional CO₂ laser, photorejuvenation, atrophic acne scars, combination therapy, efficacy, safety

CLC Number:

Zhang Meng, Zhang Shengni, Zhao Jianwei, Tian Wenying, Luo Ding, Ren Xiangxiang, Chu Ruiqi. Efficacy and safety analysis of ultrapulsed fractional CO₂ laser combined with photorejuvenation in the treatment of facial atrophic acne scars[J]. Journal of Hebei Medical College for Continuing Education, 2026, 43(3): 50-57.

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Efficacy and safety analysis of ultrapulsed fractional CO₂ laser combined with photorejuvenation in the treatment of facial atrophic acne scars

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