Abstract: Obesity and its associated metabolic syndrome and reproductive damage have become a global public health challenge. In view of the current purpose of national fat reduction and national health, it is of great practical significance to carry out the research and development of the classic prescription “Daotan Tang He Siling San”.Based on the theory of synergistic compatibility, our laboratory rationally used the medicine and food homologous Chinese medicine published by the state to replace the non-medicine and food homologous/toxic components in the original prescription, and modified the classical prescription to construct the Daotan Siling Decoction medicine and food homologous prescription( F-M DTSLD ), and carried out pharmacodynamic studies in rats. It was confirmed that F-M DTSLD had significant biological effects in reducing body weight, improving glucose and lipid metabolism disorders, inhibiting chronic inflammation, and reversing male reproductive damage caused by obesity(improving sperm quality and testicular ultrastructure). This review systematically reviews the research progress of F-M DTSLD and the research significance and prospects of F-M DTSLD, aiming to create a health product that can be integrated into the daily catering of the public, and provide solid theoretical support for promoting the scientific weight loss of the whole people and constructing the active health management model of chronic diseases.

Key words: Daotan Tang He Siling San, medicine and food homologous Fang, intervention, obesity