doi:10.3969/j.issn.1674-490X.2018.01.004

Abstract

Abstract: With the improvement of people’s lives,obese people are gradually increasing,obesity growth rate is increasingly soaring,obesity has become a human health impact of the “killer.” It is well known that inflammation plays an important role in obesity and metabolic syndrome.The low-grade chronic inflammation associated with adipose tissue is closely related to type 2 diabetes mellitus,nonalcoholic fatty liver disease,and cardiovascular disease and so on.It is known that a variety of intrinsic and adaptive immune cells are involved in regulating the inflammatory response during obesity.These immune cells include macrophages,T lymphocytes,B lymphocytes,Treg cells,etc.,which interact with adipose tissue and cause sustained low inflammatory response,increasingly aggravating metabolic disorders.Recent studies have invariantnatural killer T(iNKT)cells.Studies have shown that adipocytes express CD1d and present lipid antigens to activate iNKT cells,and the function of adipocytes is regulated by cytokines produced by iNKT cells in order to alter the expression of anti-inflammatory adipokines as well as the expression of inflammatory and chemokines production.These studies suggest that the interaction between adipocytes and iNKT cells may not only affect obesity,but also affect the development of obesity-related diseases,but iiNKT cells in obesity,the specific mechanism of action is still unclear.In this review,we summarize and discuss the latest research progress of iNKT cells in chronic inflammation of obese adipose tissue so as to make theoretical support and basic preparation for follow-up obesity and obesity-related diseases study.

Key words: iNKT cells, obesity, inflammation

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References

[1] KAER L V,LAN W.Contribution of lipid-reactive natural killer T cells to obesity-associated inflammation and insulin resistance[J].Adipocyte,2013,2(1): 10-20.DOI:10.4161/adip.22296.
[2] VAN KAER L,SMYTH M J,GODFREY D I,et al.NKT cells: What’s in a name? [J].Nature Review Immunology,2004,4(3): 230-239.DOI: 10.1038/nri1309.
[3] KRONENBERG M.Toward an understanding of NKT cell biology: Progress and paradoxes[J].Annual Review of Immunology,2005,23(2): 870-905.DOI:10.1146/annurev.immunol.23.021704.115742.
[4] TEYTON L,BENDELAC A,SAVAGE P B.The biology of NKT cells[J].Annual Review of Immunology,2007,25(4):293-338.DOI:10.1146/annurev.immunol.25.022106.141711.
[5] KAER L V.NKT cells: T lymphocytes with innate effector functions[J].Current Opinion in Immunology,2007,19(3): 352-366.DOI:10.1016/j.coi.2007.03.001.
[6] O’FARRELLY C,O’SHEA D,WINTER D C,et al.Invariant NKT cells and CD1d+ cells amass in human omentum and are depleted in patients with cancer and obesity[J].European Journal of Immunology,2009,39(2): 1890-1909.DOI:10.1111/imm.12269.
[7] SCHIPPER H S,RAKHSHANDEHROO M,VAN DE GRAAF S F,et al.Natural killer T cells in adipose tissue prevent insulin resistance[J].The Journal of Clinical Investigation,2012,12(2): 3341-3357.DOI:10.1172/JCI62739.
[8] XU A,JI Y,SUN S,et al.Activation of natural killer T cells promotes M2 macrophage polarization in adipose tissue and improves systemic glucose tolerance via interleukin-4(IL-4)/STAT6 protein signaling axis in obesity[J].Journal of Biological Chemistry,2012,287(17): 3559-3578.DOI:10.1074/jbc.M112.350066.
[9] VARGHESE B,LYNCH L,NOWAK M,et al.Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production[J].Immunity,2012,37(3): 570-589.DOI:10.1016/j.immuni.2012.06.016.
[10] PARK Y J,HUH J Y,KIM J I,et al.A novel function of adipocytes in lipid antigen presentation to iNKT cells[J].Molecular Cell Biology,2013,3(3):323-340.DOI:10.1128/MCB.00552-12.
[11] OLIVARES-VILLAGOMEZ D,WILSON M T,JOHANSSON C,et al.The response of natural killer T cells to glycolipid antigens is characterized by surface receptor down-modulation and expansion[J].Proceedings of the National Academy of Sciences of the United States of America,2003,100(10): 911-920.DOI:10.1073/pnas.1833166100.
[12] 陈昌买.小化合物FC98通过抑制代谢性炎症改善肥胖诱发的胰岛素抵抗[D].南京:南京大学,2016.
[13] 张莉亚,苗青,李益明,等.高脂饮食诱导的肥胖小鼠中缺氧对胰岛素抵抗及脂肪组织巨噬细胞浸润的影响[J].复旦学报(医学版),2015,42(4):467-472.DOI:10.3969/j.issn.1672-8467.2015.04.006.
[14] HOTAMISLIGIL G S.Inflammation and metabolic disorders[J].Nature,2006,444(7121): 859-869.DOI:10.1097/MCO.0b013e32830460c2.
[15] SALTIEL A R,LUMENG C N,BODZIN J L.Obesity induces a phenotypic switch in adipose tissue macrophage polarization[J].The Journal of Clinical Investigation,2007,117(1): 173-188.DOI:10.1172/JCI29881.
[16] SALTIEL A R,WESTCOTT D J,DEL PROPOSTO J B,et al.Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes[J].Diabetes,2008,57(1): 3229-3250.DOI:10.2337/db08-0872.
[17] NAGASAKI M,NISHIMURA S,MANABE I,et al.CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity[J].Nature Medicine,2009,15(8): 912-930.DOI:10.1038/nm.1964
[18] CIPOLLETTA D,FEUERER M,HERRERO L,et al.Lean,but not obese,fat is enriched for a unique population of regulatory T cells that affect metabolic parameters[J].Nature Medicine,2009,15(8): 924-943.DOI:10.1038/nm.2002.
[19] PALTSER G,WINER S,CHAN Y,et al.Normalization of obesity-associated insulin resistance through immunotherapy[J].Nature Medicine,2009,15(8): 919-932.DOI:10.1038/nm.2001.
[20] SHEN L,WINER D A,WINER S,et al.B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies[J].Nature Medicine,2011,17(5): 608-619.DOI:10.1038/nm.2353.
[21] LOCKSLEY R M,CHAWLA A,BANDO J K,et al.Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis[J].Science,2011,332(606): 241-250.DOI:10.1126/science.1201475.
[22] BANDYOPADHYAY G,TALUKDAR S,OH D Y,et al.Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase[J].Nature Medicine,2012,18(9): 1403-1417.DOI:10.1038/nm.2885.
[23] FERRANTE A W Jr,LEIBEL R L,ROSENBAUM M,et al.Obesity is associated with macrophage accumulation in adipose tissue[J].The Journal of Clinical Investigation,2003,112(12): 1794-1810.DOI:10.1172/JCI19246.
[24] QI L,LI X,YANG L,et al.Short term high fat diet challenge promotes alternative macrophage polarization in adipose tissue via natural killer T cells and interleukin-4[J].Journal of Biological Chemistry,2012,287(24):373-387.DOI:10.1074/jbc.M112.371807.
[25] WINGENDER G,HEDRICK C C,KRAUSE P,et al.IL-10-producing NKT10 cells are a distinct regulatory invariant NKT cell subset[J].The Journal of Clinical Investigation,2014,124(9): 3725-3740.DOI:10.1172/JCI72308.
[26] KOAY H F,TIGHE M,BESRA G,et al.Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T(reg)cells and macrophages in adipose tissue[J].Nature Immunology,2015,16: 78-97.DOI:10.1038/ni.3047.
[27] MARGALIT M,SHALEV Z,PAPPO O,et al.Glucocerebroside ameliorates the metabolic syndrome in OB/OB mice[J].J Pharmacol Exp Ther,2006,319: 105-110.DOI:10.1124/jpet.106.104950.
[28] ELINAV E,PAPPO O,SKLAIR-LEVY M,et al.Adoptive transfer of regulatory NKT lymphocytes ameliorates non-alcoholic steatohepatitis and glucose intolerance in ob/ob mice and is associated with intrahepatic CD8 trapping[J].J Pathol,2006,209: 121-128.DOI:10.1002/path.1950.
[29] LOMENICK J P,BESRA G S,BRACY D P,et al.Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation,insulin resistance and hepatic steatosis in obese mice[J].Proceedings of the National Academy of Sciences of the United States of America,2012,109: E1141-E1159.DOI:10.1073/pnas.1200498109.
[30] OHMURA K,ISHIMORI N,OHMURA Y,et al.Natural killer T cells are involved in adipose tissues inflammation and glucose intolerance in diet-induced obese mice[J].Arteriosclerosis Thrombosis & Vascular Biology,2010,30(2): 193.DOI:10.1161/ATVBAHA.109.198614.
[31] SATOH M,ANDOH Y,CLINGAN C S,et al.Type II NKT cells stimulate diet-induced obesity by mediating adipose tissue inflammation,steatohepatitis and insulin resistance[J].PLoS One,2012,7(2): e30568.DOI:10.1371/journal.pone.0030568.
[32] SUBRAMANIAN S,TURNER M S,DING Y,et al.Increased levels of invariant natural killer T lymphocytes worsen metabolic abnormalities and atherosclerosis in obese mice[J].Journal of Lipid Research,2013,54(10): 2831.DOI:10.1194/jlr.M041020.
[33] O’DOHERTY R M,DEDOUSIS N,YANG X,et al.Mice lacking NKT cells but with a complete complement of CD8+ T-cells are not protected against the metabolic abnormalities of diet-induced obesity[J].PLoS One,2011,6: e19831.DOI:10.1371/journal.pone.0019831.

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