Research on expression of PDGF in small bowel transplantation in rats

Abstract

Abstract: Objective To analyse the expression of PDGF in small bowel transplantation in rats. Methods Isogeneic and allogeneic small bowel transplantation were performed in rats with microsurgical technology. Recipients were divided into two groups:isogeneic control group and allogeneic test group. Graft tissues were harvested on POD7, POD28 and POD90. mRNA transcription and immunohistochemical staining were also performed to detect the expression of PDGF. Results The expression of PDGF showed ascending tendency in whole stage, and the results of test group of POD90 were significantly higher than that of other stages. The immunohistochemical staining showed a higher expression in graft tissue in test group. Conclusion PDGF is highly expressed in the end stage of small bowel transplantation, and shows meaningful use for examination of chronic rejection.

Key words: PDGF, small bowel transplantation, chronic rejection

CLC Number:

R361

References

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