Abstract: Objective To observe the process of treatment and the role of attenuated effects in the rheumatoid arthritis (RA) treatment with Shengyangyiwei method. Methods 150 patients with RA were randomly divided into two groups. 75 patients in the control group while 75 patients in the treatment group. Both groups were treated with Methotrexate Nimesulide and methylprsdnisone, while the former was added with pantoprazole sodium capsules, and the later was added with Shengyangyiwei Tang treatment. The gastric mucosal injury and gastrointestinal symptoms were observed respectively before treatment and after treatment for 30 d and 90 d. ALT、ESR、CRP of the patients were observed after treating for 30 d and 90 d. Results After 90days’ treatment, the gastric mucosal injury and gastrointestinal symptoms in the patients of the experimental group were significantly lower than that of the control group.Therefore, the differences of the total efficiency in both groups were statistically significant. (With P<0.05). As for ALT, ESR and CRP comparison, the results of the treatment group was significantly better than that of the control group, the differences were significant (P<0.05). conclusion The Shengyangyiwei Tang can effectively prevent and control the digestive side effects in RA therapy and with significant treatment effects, at the same time it has good curative effects to improve symptoms, control the disease progress etc.

Key words: Shengyangyiwei Tang, rheumatoid arthritis, digestive system