The changes of serum amyloid A (SAA), plasma D-dimer and tumer marker CA724 for predicting tumor metastasis of patients with colorectal cancer

doi:10.3969/j.issn.1674-490X.2014.01.004

Abstract

Abstract: Objective To explore the changes of serum amyloid A (SAA), plasma D-dimer and tumer marker CA724 for predicting tumor metastasis of patients with colorectal cancer. Methods Preoperative SAA, D-dimer and CA724 were measured in 58 patients with colorectal and 55 patients with benign disease, and they were analyzed with statistics method. In addition, according to pathological TNM (AJCC/UICC TNM), the patients with colorectal were divided into no metastasis group, regional lymph node metastasis group and distant metastasis group for comparing SAA, D-dimer and CA724 between groups. Results SAA, D-dimer and CA724 levels were signiifcantly higher in patients with colorectal carcinoma than those with benign diseases (P<0.05). SAA test showed that there was statistical significance between no metastasis group, regional lymph node metastasis group and distant metastasis group, and there was no statistical signiifcance by CA724. SAA and D-dimer levels in distant metastasis group were obviously higher than that of no metastasis group and regional lymph node metastasis group (P<0.05). Conclusion There is guiding signiifcance for conifrming regional lymph node metastasis and distant metastasis in patients with colorectal to detect SAA CA724 and D-dimer levels.

Key words: colon carcinoma and rectal carcinoma, serum amyloid A, CA724 antigen, D-dimer

CLC Number:

HU Ling,SU Lei,SHANG Yanhong,WANG Zhiyu,LI Xiaofang,JIAO Jin,CHEN Chunyan. The changes of serum amyloid A (SAA), plasma D-dimer and tumer marker CA724 for predicting tumor metastasis of patients with colorectal cancer[J]. Medical Reserch and Education, 2014, 31(1): 17-20,45.

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