Abstract: Objective To discuss the clinical effect of irbesartan combined with amiodarone in rebuilding and maintaining sinus rhythm in patients with paroxysmal atrial fibrillation. Methods 100 patients with paroxysmal atrial fibrillation randomly were divided into control group (n=48) and therapeutic group (n=52).Both groups received amiodarone, therapeutic group received irbesartan additionally.All patients were follwed up for 1year. The diameter of left atrium (LAD), left ventricular ejection fraction (LVEF) and the level of hs-CRP were counted, The rate of successful sinus rhythm rebuilding and its maintenance were also observed. Results Compared with the control group, the LAD decreased and LVEF improved in therapeutic group, the rate of successful sinus rhythm and its maintenance were significantly increased. The level of hs-CRP in both groups was lower, especially in the therapeutic group. Conclusion Irbesartan combined with amiodarone can inhibit atrial remodeling obviously, improve heart function, increase the rate of in the rebuilding of sinus rhythm and decrease its recurrence rate significantly, which is more effective than amiodarone alone.

Key words: irbesartan, amiodarone, high sensitivity C reactive protein, paroxysmal atrial fibrillation