Abstract: Objective To investigate the relationship between plasma Brain natriuretic peptide(BNP) level and left ventricular wall motion score index (LVWMSI) in patients with acute ST-segment elevation myocardial infarction (STEMI), and the short term prognosis within 180 days. Methods Sixty four patients with STEMI were treated with primary percutaneous coronary intervention (p-PCI) within 12 h of onset. The BNP level was measured on admission. Based on the BNP level, all patients were divided into four groups (according to the 4 percentile): group A (BNP≤P25: BNP≤115.25 pg/mL), group B(P26≤BNP≤P50: 115.26-200.5 pg/mL), group C(P51≤BNP≤P75: 200.6 -409 pg/mL)and group D(BNP≥P76: BNP≥409 pg/mL). The relationship of BNP level with LVWMSI was analysised. The major adverse cardiac events (MACE) within 180 days were also analyzed. Results The difference of left ventricular wall motion score index among different groups were statistical significant (P<0.05). The levels of BNP and LVWMSI was positively related(r=0.73, P<0.01).Along with the increase of plasma BNP level, major adverse cardiac events increased significantly (P<0.05). Conclusion Plasma BNP level provides information about the change of heart function and short term prognosis for acute myocardial infarction patients.

Key words: B-type natriuretic peptide, left ventricular wall motion score index, acute ST-segment elevation myocardial infarction, primary percutaneous coronary intervention, major adverse cardiac events