Abstract: Objective To investigate the effects of target-controlled intravenous anesthesia on hemodynamics, stress response and recovery quality during perioperative period in elderly patients undergoing abdominal surgery. Methods 120 elderly patients who were treated with abdominal surgery in March 2016-September 2017 were randomly divided into observation group and control group(60 cases in each group). The patients in observation group were given propofol-fentanyl combined with target-controlled intravenous anesthesia, the patients in control group were given fentanyl combined with 2.5% isoflurane inhalation combined anesthesia, the average arterial pressure(MAP), heart rate(HR), and 4 periods of 10min(T3)were observed in two groups before anesthesia(T0), induced intubation(T1), extubation(T2)and extubation. The hemodynamic indexes such as blood oxygen saturation(SpO₂)and the changes of stress indexes such as endothelin(ET)and cortisol(Cor), as well as the recovery quality indexes such as the time of spontaneous respiration, the open time, the full awake time, the extubation time and the steward awakening score. Results T0 and T3, there was no statistically significant difference between the two groups of map and HR levels(P>0.05). T1-T2, the observation group map, the HR level was obviously lower than that of the control group, the comparison difference had the statistical significance(P<0.05). There was no statistically significant difference between ET and Cor levels in the two groups of T0(P>0.05). T1-T3, the level of ET and Cor in the observation group was significantly lower than that in the control group, and the difference was statistically significant(P<0.05). The recovery quality indexes of the observation group were significantly superior to those of the control group, such as the time of spontaneous respiration, the open time, the full awake time, the extubation time and the steward recovery score, and the difference was statistically significant(P<0.05). Conclusion Propofol combined with Shutefini target-controlled intravenous anesthesia can significantly reduce the perioperative hemodynamic changes and stress responses in elderly patients with abdominal surgery.

Key words: target-controlled intravenous anesthesia, elderly, hemodynamics, stress response