Abstract: Objective To learn the prevalence rate and related risk factors of the nosocomial infection in our hospital,and to explore the prevention and control measures through investigating the prevalence rate of hospital infection from 2014 to 2016 and provide scientific basis for the prevention and control of hospital infection. Methods The investigation of by bed,case survey and cross-sectional survey was performed, the nosocomial infection of all the hospitalized patients and the use of antibacterial agents in 2014,2015,and 2016 were analyzed. Results The hospital infection rates were 2.73%,2.08%and 2.39% in 2014,2015 and 2016 with no statistically siginificant difference. The cases infection rates were 3.00%,2.15%and 2.53% in the 3 years, which had no significant difference.The lower respiratory tract was the uppermost parts of the hospital infection, followed by the upper respiratory tract and urinary tract. The etiology delivering rate had no obvious difference in the recent 3 years.The lowest rate of antibacterial agents usage was 29.49% in 2016, with a sharply decrease compared in 2014(36.61%),2015(35.63%).Urinary tract intubation and mechanical ventilation were the two factors causing the risk factor of hospital infection. Conclusion The hospital infection rates in accordance with relevant state regulations. we should continue to strengthen the whole hospital of training of “three great managements”and “falling training”. we should strengthen the urinary tract and respiratory tract intubation of sterile operation, strengthen care, daily assessment and remove the tube as early as possible. In addition, the hospital infection rates now conform to the related national requirements in hospital, we should strengthen the control of antibiotics, guide the rational use of antibiotics, doctors should apply antibiotics in time and properly microbiological specimens should be examined before the usage.

Key words: hospital infection, prevalence rate, cross-sectional survey, hantibacterialh agents, prevention and control measure