Journal of Hebei Medical College for Continuing Education

Preliminary study on the extraction of Gecko extract and its anti-tumor activity

SONG Jiayu,YOU Yanjie

2016, 33(5): 1-5. DOI: 10.3969/j.issn.1674-490X.2016.05.001

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Objective To optimize the extraction process of Gecko extract and preliminarily assess its antitumor activity in vitro.Methods We used approaches of ultrasonication and extraction with ethanol,and performed orthogonal tests upon univariate analysis.Results Our results revealed the optimal extraction conditions as follows:the ratio of material to solvent(1∶4),ultrasonic time(30 min),ultrasonic power(400 W),and final concentration of ethanol(55%).Thus,the yield of Gecko extract was about 6.5% and the total content of protein included was about 23.15%.Conclusion The results showed that exposure to Gecko extract dramatically suppressed the proliferation of esophageal carcinoma EC-109 cells and prostatic cancer PC-3 cells in a dose and time-dependent manner.

Expression of RECK in endometrial carcinoma and its correlation with MMP-9

WU Fenglan

2016, 33(5): 6-9. DOI: 10.3969/j.issn.1674-490X.2016.05.002

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Objective To study the expression of RECK and MMP-9 in endometrial carcinoma and its clinical significance. Methods The endometrial cancer specimens from April 2012 to January 2015 in The First Affiliated Hospital of Luohe Medical College and confirmed by surgery and pathologically were detected by immunohistochemical S-P method to analyze the expression of RECK and MMP-9 and their correlation. Results The positive expression rate of RECK gene inendometrial carcinoma was significantly higher than that in control group,35% and 84.4% respectively, and the positive expression rate of group I in endometrial carcinoma was significantly higher than that in group Ⅱ-Ⅳ,51.4% and 12% respectively, and the difference was significant(P<0.05). The positive rate of MMP-9 in normal endometrium was significantly lower than that in endometrial carcinoma, 17.8% and 76.7%, respectively. The positive rate of group I in endometrial carcinoma was significantly lower than that in group Ⅱ-Ⅳ, 65.7% and 92% respectively, and the difference was significant(P<0.05). The expression of MMP-9 was negatively correlated with RECK(P<0.05, r=-0.390).Conclusion The expression of RECK and MMP-9 plays an important role in the occurrence and development of endometrial cancer and has important significance to judge the prognosis.

Application of replacement therapy in children with chronic sinusitis

HUANG Zhuoliang, SHANG Liping

2016, 33(5): 10-12. DOI: 10.3969/j.issn.1674-490X.2016.05.003

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Objective To study the effects of replacement therapy in children with chronic sinusitis. Methods Sixty-nine children with chronic sinusitis were recruited and divided into two groups. The patients in the observation group were treated with replacement therapy from March 2012 to May 2014, and the control group Children with conventional drug therapy to observe the results of treatment. Results The total effective rate was 94.29% in the experimental group(P<0.05), which was higher than that of control group. Conclusion Replacement therapy is an important method for the treatment of chronic sinusitis in children.

Analysis on national famous old doctor of traditional Chinese medicine on diabetic nephropathy syndrome differentiation and its treatment rules

LI Yuan, QI Xiangmei,CHEN Huangzhen

2016, 33(5): 13-20. DOI: 10.3969/j.issn.1674-490X.2016.05.004

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Objective To explore the treating rules of some national famous old doctors of traditional Chinese medicine’s medication for diabetic nephropathy(DN).Methods The treatment rules of diabetic nephropathy in 60 national famous old doctors of traditional Chinese medicine were collected, auxiliary system software,the inheritance of traditional Chinese medicine, the software integration analysis, improved mutual information method, the complex system entropy and entropy of unsupervised clustering hierarchy clustering data mining methods were applied. Results In the 71 selected consilia, the appearance frequency of symptoms and the frequency of each herb and association rules among the herbs were computed, 26 core combinations and 6 new prescriptions were also mined from the database. Conclusion Data analysis methods can be used to find the national famous old doctor of traditional Chinese medicine in the treatment of diabetic nephropathy.

Introduction to the effects of extended nursing care on the quality of life of patients with cirrhosis

LYU Li

2016, 33(5): 21-24. DOI: 10.3969/j.issn.1674-490X.2016.05.005

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Objective To observe the effects of extended care on the quality of life of patients with cirrhosis. Methods 76 patients with cirrhosis hospitalized in the Erdao Disrtict People’s Hospital of internal medicine from March 2014 to August 2015 were selected.The cases were randomly divided into experimental group(38 cases)and control group(38 cases).Patients in control group were treated with routine nursing care. Patients in the experimental group were treated with routine care and extended nursing care for 6 months after leaving hospital. By filling out the questionnaire, the relevant data of the two groups of patients in the quality of life, life field, psychological field, the field of independence, environmental field and the field of social relations were compared. Results The quality of life of patients in the experimental group was significantly higher than that of the control group for after their discharge from hospital 6 months(P<0.05).Conclusion Extended nursing care for patients with cirrhosis after discharge can improve the degree of patients’ understanding of the disease, and improve the quality of life.

Effects of health education on blood glucose and psychological changes in patients with type 2 diabetes

HUANG Qun,LIU Jinxia,DU Luanying,GUO Yachun,LI Jiantuan

2016, 33(5): 25-29. DOI: 10.3969/j.issn.1674-490X.2016.05.006

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Objective To investigate the effects of health education pathway on blood glucose and psychological changes in patients with type 2 diabetes. Methods 260 patients with type 2 diabetes were randomly divided into 2 groups,the patients in the experimental group were implemented health education path of type 2 diabetes during the period of hospitalization and the patients in the control group continued to use routine nursing measures.Knowledge and skill levels of type 2 diabetes and blood glucose control rate were observed in the experimental group and control group.Patients’ psychology was tested by using Zung Depression Scale and Zung Anxiety Scale. Results Compared with the control group,the knowledge and skill levels of type 2 diabetes,blood glucose control rate,glycosylated hemoglobin control rate,anxiety and depression were significantly improved in the experimental group(P<0.01). Conclusion The implementation of a comprehensive system of health education path on type 2 diabetes can control the disease of type 2 diabetic patients,reduce the patient's depression and anxiety,improve the patient’s compliance of patients with treatment and nursing strategies and improve the quality of life.

Developments on acute respiratory distress syndrome induced by sepsis

JU Hailong,ZHOU Yinglian,LIU Peng,ZHANG Xinxin,PENG Guangjun

2016, 33(5): 30-34. DOI: 10.3969/j.issn.1674-490X.2016.05.007

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Severe sepsis or septic shock is characterized by an excessive inflammatory response to infectious pathogens.Acute respiratory distress syndrome(ARDS)is a devastating complication of severe sepsis,in which patients have high mortality.Advances in treatment modalities including lung protective ventilation,prone positioning,use of neuromuscular blockade,and extracorporeal membrane oxygenation,have improved the outcome over recent decades,nevertheless,the mortality rate still remains high.Timely treatment of underlying sepsis and early identification of patients at risk of ARDS can help to decrease its development.In addition,further studies are needed regarding pathogenesis and novel therapies in order to show promising future treatments of sepsis-induced ARDS.

The application status of anticoagulant drugs in systemic lupus erythematosus

CHENG Yanhong,HAO Bin

2016, 33(5): 35-39. DOI: 10.3969/j.issn.1674-490X.2016.05.008

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Systemic lupus erythematosus is an autoimmune disease which could be involved in every system all over the body.And its pathogenesis is immune-mediated vasculitis.In numerous studies,we can find that the anticoagulants have been used in treatment of system lupus erythematosus(SLE)and its complications,and it becomes more and more popular.What more,as an adjunctive therapy for the systemic lupus erythematosus,traditional Chinese medicine also been added in,such as blood circulation drugs.This article reviews research progress on the application of anticoagulant drugs in systemic lupus erythematosus.

Advances on chronic heart failure in minipig models

YING Chenting,FAN Ziyu,NIU Xiaolong

2016, 33(5): 40-43. DOI: 10.3969/j.issn.1674-490X.2016.05.009

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Chronic heart failure(CHF)is a complex cardiovascular syndrome.The establishment of an appropriate animal model of CHF is crucial for the study of pathogenesis and pharmacotherapy in CHF.Porcine models of chronic heart failure have became imperative because minipig is closer to human in physiopathology and anatomy.In recent years,the commonly used methods of minipig models of CHF are myocardial infarction,volume overload,pressure overload,drug-induced and ventricular rapid pacing.

Advances on the role of interleukin-6 in the pathogenesis of psoriasis

SUN Haiyan,DING Qiuyun,SHI Yijun,CHU Ruiqi

2016, 33(5): 44-48. DOI: 10.3969/j.issn.1674-490X.2016.05.010

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Psoriasis is a chronic inflammatory skin disease characterized by increased epidermal thickness.The causes of the disease are complex,many people believe it is an autoimmune-related skin disease.The course of the disease is long,and the recurrent attacks of the disease are easy.Interleukin 6(IL-6)can induct differentiation and proliferation of keratinocytes and induce the activation of T cells,stimulate keratinocytes to produce cytokines including vascular endothelial growth factor(VEGF),IL-8,these cytokines may play important roles in the development or aggravation of psoriasis,IL-6 is also related to psoriasis-caused osteoporosis,hyperlipidemia,and cardiovascular diseases.

Developments on symptom clusters in patients with advanced lung cancer

ZHANG Jine,CHI Liwei,ZANG Yu

2016, 33(5): 49-52. DOI: 10.3969/j.issn.1674-490X.2016.05.011

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It describes the research progress on advanced lung cancer symptom clusters from the known lung cancer symptom clusters,the influencing factors of lung cancers symptom clusters and the connection between lung cancer symptoms clusters and clinic.Recognition of these symptom clusters is useful for medical workers to assess and provide effective interventions,which are conducive to symptom control and prevention and the improvement of life quality.

Advances on the study of the relationship between hypothyroidism and infertility

CHANG Yaqing,KONG Hongfang,WANG Fengnuan,XIN Hong

2016, 33(5): 53-58. DOI: 10.3969/j.issn.1674-490X.2016.05.012

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In recent years,the incidence of female infertility is increasing,studies have shown that it is closely related to the regulation of gonad axis and sex hormones.Thyroid disease has long been a concern,it is the second most common endocrine disorders in women of childbearing age,including hypothyroidism and thyroid dysfunction related which is the most common in clinical.With the deepening of the study of these two diseases and related hormones,the correlation between the two is deepened.When the thyroid gland axis and related hormone levels changed,the gonad axis and the regulation of ovarian function are going to be affected,causing a corresponding change of the sex hormone levels to a certain extent.Consequently,the relationship between thyroid hormone,sex hormone,thyroid axis and gonad axis plays an important role in normal pregnancy process.The progresses of researches about the correlation between hypothyroidism and thyroid dysfunction related and infertility are summarized.

Advances on diagnosis and treatment of calcaneal fractures

SUN Yuming,LIU Yongjia

2016, 33(5): 59-62. DOI: 10.3969/j.issn.1674-490X.2016.05.013

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Calcaneal fractures are more common in clinical tarsal bone fracture,occupying 60% of tarsal bone fracture,account for approximately 1% to 2% of body fracture,disability rate is as high as 30%.They are mainly caused by falling down,car accidents or injured,patients are mostly young adults,the disease severely affects the level of social productive forces,thus,which is widely concerned.With the development of science and technology,more and more diagnosis and treatment of calcaneal fractures are developed,only the accurate diagnosis and proper treatment can make the patients recover.The following review will discuss the diagnosis and treatment of calcaneal fractures.

Exploration of self-study on emergency medicine knowledge for pharmic undergraduate

LEI Yingjie,LIU Xiujie,DING Mei

2016, 33(5): 63-66. DOI: 10.3969/j.issn.1674-490X.2016.05.014

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With the development of medical care,the popularization of first-aid and emergency medicine knowledge has become a focus in the field of medicine.With a view to the less capability of clinical thinking to pharmic undergraduate,the proposal of adding the train of emergency medicial knowledge to the pharmic undergraduate was suggested,in which some teaching methods such as students presentation,class discussion and the scenario simulation operation to promote the efficiency of self-study are discussed,so that the goal of strengthening the clinical thinking and professional quality to pharmic undergraduate can be achieved.

The application of cooperative learning approach in teaching electrocardiography

GE Qian, LIAO Kui

2016, 33(5): 67-70. DOI: 10.3969/j.issn.1674-490X.2016.05.015

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Objective To train the clinical medical students to better study the diagnosis of electrocardiography by using the cooperative learning approach. Methods For the traditional lecture-style teaching approach, the teachers explained the diagnostic points by using multimedia slides. For the cooperative learning approach, the students competed for the diagnosis of electrocardiography between groups. The teachers rewarded the winners and summarized the diagnostic points. At the end of term, the students were surveyed by questionnaire. Results Compared with the students who received the lecture-style teaching approach, the students who received the cooperative learning approach had higher degree of satisfaction. The vast majority of students ［98.54%(135/137)］ applauded this approach. There were 91.97%(126/137)of students who thought the cooperative learning could promote and consolidate theoretical knowledge of electrocardiograph. 87.59%(120/137)of students admited their improvements in clinical thinking ability. 91.24%(125/137)of students agreed it could improve the ability of diagnosis. 94.89%(130/137)of students felt more interested in electrocardiography learning and most students ［96.35%(132/137)］ enjoyed the relaxed class atmosphere.Conclusion The application of cooperative learning approach could effectively improve the abilities of students in electrocardiography diagnosis.

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