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Advances on the pharmacological effects and molecular mechanisms of Icaritin WU Di, MI Tian, WANG Hedong, WANG Junfei, LI Wenjuan Journal of Hebei Medical College for Continuing Education    2023, 40 (6): 1-11.   DOI: 10.3969/j.issn.1674-490X.2023.06.001 Abstract （502）      PDF（pc） （1195KB）（425）       Knowledge map    Save Icaritin, as a single active ingredient of the Chinese herbal medicine Epimedium, shows a wide range of pharmacological activities, such as anti-inflammatory, immunomodulatory, cardiovascular protection, bone protection and antioxidant, etc. Meanwhile, Icaritin has an inhibitory effect on different tumors through blocking the cell cycle, promoting apoptosis, metastasis inhibition and immunomodulation. This paper reviews the chemical composition of icaritin and the latest research progress at home and abroad in anti-tumor activity, non-anti-tumor pharmacological effects. This review focus on the chemical composition of icaritin and the latest research progress in anti/non-anti-tumor pharmacological effects to provide a theoretical basis for the further development of Epimedium and its precise clinical application. Reference | Related Articles | Metrics | Comments（0）

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Application of external treatment of TCM in relieving fever in patients with exogenous fever MA Wenjing, LI Chaojun, XU Haixia, LIU Nina Journal of Hebei Medical College for Continuing Education    2023, 40 (6): 54-60.   DOI: 10.3969/j.issn.1674-490X.2023.06.008 Abstract （224）      PDF（pc） （499KB）（59）       Knowledge map    Save Fever is not only the first symptom of many diseases, but also the only symptom of some diseases. In recent years, there has been a significant increase in the number of consultations for fever due to external evils, as a result of the frequent occurrence of infectious diseases caused by viruses and bacteria. Modern medicine is based on antipyretic, antiviral and/or antibiotic medication, which is effective in reducing fever, but also requires acceptance of its side effects and repeated medication when fever tends to recur. In contrast, the external treatment methods of Chinese medicine are not only highly effective, simple, with few side effects, but are also more acceptable to patients and their families and easy to use at home. This paper reviews the effectiveness and characteristics of the application of common TCM external treatment methods to reduce fever, such as guasha, cupping, bloodletting, acupressure, acupoint application, herbal baths and herbal enemas, in the care of patients with exogenous fever in recent years to provide reference for clinical formulation of fever reduction protocols. Reference | Related Articles | Metrics | Comments（0）

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Pressure-controlled volume guaranteed ventilation in clinical application WANG Jianlong, GUO Haoyuan, GONG Zhexuan, ZHANG Yin'en, WU Guangyi Journal of Hebei Medical College for Continuing Education    2023, 40 (6): 28-33.   DOI: 10.3969/j.issn.1674-490X.2023.06.004 Abstract （217）      PDF（pc） （438KB）（117）       Knowledge map    Save Perioperative mechanical ventilation-induced lung injury has become a globally recognized issue, and enhancing perioperative lung protection can significantly reduce the occurrence of pulmonary complications and promote early patient recovery. There have been studies indicating a close relationship between intraoperative mechanical ventilation strategies and perioperative lung injury. Pressure-Controlled Volume Guaranteed Ventilation(PCV-VG)is an emerging ventilation mode that can provide stable tidal volumes without being affected by changes in airway pressure. It achieves appropriate ventilation and oxygen supply by ensuring that the airway pressure remains within a predetermined limit. This review is to comprehensively evaluate the impact of PCV-VG mode on perioperative lung injury and outcomes, including hemodynamics, respiratory mechanics, inflammatory mediators, oxygenation indices, and postoperative complications, among other key factors. It also aims to compare the application effects of different ventilation modes in specific patient populations, providing more reliable evidence for clinicians in choosing ventilation strategies. Reference | Related Articles | Metrics | Comments（0）

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Advances on self-regulation in disease management of patients with chronic diseases HE Xiaoge,LU Qian,ZHU Fei,KE Sangsang,WANG Jingwei,LIU Chunlei Journal of Hebei Medical College for Continuing Education    2023, 40 (6): 61-68.   DOI: 10.3969/j.issn.1674-490X.2023.06.009 Abstract （197）      PDF（pc） （485KB）（108）       Knowledge map    Save Self-regulation is a key variable of disease self-management in patients with chronic diseases and influences the establishment of health behaviors. This article reviews the related theories, assessment tools, influencing factors, and interventions of self-regulation in patients with chronic diseases, aiming to enhance the attention of domestic researchers to self-regulation in patients with chronic diseases and help patients to manage their diseases effectively by improving the level of self-regulation and provide reference for future research. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2024, 41 (1): 71-75.   DOI: 10.3969/j.issn.1674-490X.2024.01.010 Abstract （159）      PDF（pc） （446KB）（39）       Knowledge map    Save The applications of aromatherapy in chemotherapy related nausea and vomiting(CINV)in cancer patients were summarized in order to provide a detailed introduction to the concept, classification, pathogenesis, and prevention and treatment measures of chemotherapy related nausea and vomiting; The definition, origin and development, operation method, mechanism of action, application status in modern clinic and application status in CINV of cancer patients of aromatherapy were introduced, and the existing problems and follow-up research directions were discussed to provide reference for the related care of this method in CINV of cancer patients. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2024, 41 (3): 76-80.   DOI: 10.3969/j.issn.1674-490X.2024.03.011 Abstract （153）      PDF（pc） （383KB）（59）       Knowledge map    Save With the continuous progress of technology and the rapid development of artificial intelligence technology, the application of multimodal artificial intelligence in nursing education has become a trend. The ability of multimodal AI to process multiple data modalities from different perceptual sources opens up new opportunities for innovation in nursing education. The purpose of this paper is to explore the application of multimodal AI in nursing education and analyze its future trends. Reference | Related Articles | Metrics | Comments（0）

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Study on the differences between teaching film-reading and case discussion in standardized resident training LI Wei, LI Wen, JIANG Shuqin, ZHANG Rusen, ZHANG Linqi, PENG Hao Journal of Hebei Medical College for Continuing Education    2023, 40 (6): 75-80.   DOI: 10.3969/j.issn.1674-490X.2023.06.011 Abstract （144）      PDF（pc） （352KB）（74）       Knowledge map    Save In the standardized resident training, clinical instruction teachers in the medical imaging profession have obvious confusion about how to carry out teaching film-reading, with the main confusion is how to accurately distinguish between teaching film-reading and teaching case discussion. Deeply considering this and constructing the key points for distinguishing between them is beneficial for the standardized development of standardized resident training in medical imaging majors. Based on the differences in the core ideas between teaching film-reading and case discussion, the differences in teaching content, case sources, image analysis, classroom performance are discussed. This will help clinical instruction teachers to correctly understand and carry out teaching film-reading and avoid confusion with case discussion Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2024, 41 (1): 18-26.   DOI: 10.3969/j.issn.1674-490X.2024.01.003 Abstract （140）      PDF（pc） （505KB）（54）       Knowledge map    Save Platinum drugs are one of the most effective chemotherapy drugs for ovarian cancer, and although the initial response to platinum chemotherapy is as high as 80%, resistance is common. In most advanced patients, eventual relapse and death are caused by acquired resistance. Chemotherapy resistance of ovarian cancer is a major obstacle affecting its therapeutic effect. However, the cause of chemotherapy resistance is unclear and the mechanism is complex, which is a difficult and hot point in clinical and scientific research. Therefore, the study of drug resistance mechanism of ovarian cancer will provide a basis for the exploration and development of chemotherapy for ovarian cancer.This article reviews the molecular mechanism of platinum resistance in ovarian cancer. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2024, 41 (3): 8-17.   DOI: 10.3969/j.issn.1674-490X.2024.03.002 Abstract （127）      PDF（pc） （555KB）（40）       Knowledge map    Save Post-stroke survivors usually face limb movement disorders, balance disorders and cognitive impairment, and traditional rehabilitation training cannot support their better return to family and social life. The advantages of the effective combination of cognitive and motor training in stroke patients have been confirmed in a large number of studies, but its recovery of cognitive function and motor function is not always a positive effect. Therefore, this article summarizes the effects of cognitive motor dual task training mode on cognitive function and motor function in stroke patients, and discusses its application progress in the rehabilitation process of stroke patients. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2024, 41 (1): 62-70.   DOI: 10.3969/j.issn.1674-490X.2024.01.009 Abstract （119）      PDF（pc） （515KB）（25）       Knowledge map    Save The perceived risk of disease recurrence is the basis for individuals to accept preventive behaviors, and it is important to raise patients' awareness of the risk of recurrence and reduce the rate of disease recurrence. This article describes the concepts related to risk perception, single-dimensional and multi-dimensional of assessment tools, and summarizes the influencing factors and coping strategies of perceived risk of disease recurrence in stroke patients, aiming to help healthcare professionals better understand the importance of assessing the perceived risk of recurrence, and to provide new ideas for clinical workers to carry out disease recurrence management and related interventions. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2024, 41 (1): 9-17.   DOI: 10.3969/j.issn.1674-490X.2024.01.002 Abstract （118）      PDF（pc） （495KB）（36）       Knowledge map    Save It has been shown that the human gut is settled with a large microbiota, which is involved in the regulation of the body's immune homeostasis and is closely related to the development of ischaemic stroke. The discovery of the microbial-gut-brain axis links the gut to the brain and plays an important role in human health and disease processes. This paper reviews the regulatory mechanisms of the microbial-gut-brain axis, the modulation of gut flora and its metabolites after stroke, and the possible mechanisms of the brain-gut axis based on brain and gut immune responses after ischaemic stroke. These studies provide important implications for exploring new directions of gut and brain immunotherapy after stroke and improving stroke prognosis. Reference | Related Articles | Metrics | Comments（0）

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Advances on the role of iron and vitamin D in children's growth and development WANG Yuru, JI Rui, ZOU Jingwen, YUAN Bo, BAI Jinxiu Journal of Hebei Medical College for Continuing Education    2023, 40 (6): 21-27.   DOI: 10.3969/j.issn.1674-490X.2023.06.003 Abstract （118）      PDF（pc） （477KB）（145）       Knowledge map    Save Children are at the most important stage of growth and development in a person's life, and the most commonly used indicators to evaluate physical development in children are height, weight and BMI. Iron and vitamin D play a vital role in children's growth and development. However, there are relatively few articles about the role of iron and vitamin D in children's growth and development. This article provides a systematic review of the current role of iron and vitamin D in childhood height growth and obesity,aiming to provide a scientific basis for the monitoring of iron and vitamin D levels and nutritional supplementation in the future, and to make clinicians pay more attention to the role of iron and vitamin D in children's growth and development. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2024, 41 (2): 56-62.   DOI: 10.3969/j.issn.1674-490X.2024.02.008 Abstract （108）      PDF（pc） （456KB）（9）       Knowledge map    Save This paper introduces the relevant research developments on hospice training for emergency medical workers both domestically and internationally, focusing on the summary of the training content, training methods and evaluation forms, puts for forward some suggestions for conducting hospice training for medical workers on emergency department in China, and provides reference for the construction of training courses for localized emergency department in medical workers on hospice. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2024, 41 (2): 9-14.   DOI: 10.3969/j.issn.1674-490X.2024.02.002 Abstract （108）      PDF（pc） （458KB）（193）       Knowledge map    Save Chronic obstructive pulmonary disease(COPD), as a common and frequently occurring respiratory disease in clinical practice, is mainly classified into bronchitis and emphysema based on long-term clinical theory and practice. With the widespread application of high-resolution CT, CT scans of some patients with COPD show the presence of bronchiectasis. The repeated respiratory infections caused by bronchiectasis exacerbate the decline of lung function and the development of respiratory failure. Therefore, further research is needed on the special phenotype, pathogenic factors, pathogenesis, and clinical treatment of COPD combined with bronchiectasis. Through a comprehensive analysis of the pathogenesis and clinical treatment theories of chronic obstructive pulmonary disease with bronchiectasis in recent years, we can further understand this disease. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2024, 41 (1): 76-80.   DOI: 10.3969/j.issn.1674-490X.2024.01.011 Abstract （98）      PDF（pc） （427KB）（21）       Knowledge map    Save Military vocational education is an important part of the new trinity military personnel training system, which plays an important role in improving the ability and quality of military personnel and improving their post competence. The vocational education of military doctors in grass-roots units is an important measure and effective means to rapidly improve the medical rescue ability of grass-roots military doctors in peacetime and wartime. Focusing on the needs of medical service in grass-roots units, this teaching and research section has carried out a series of reforms and explorations on the basis of the previous experience of ultrasonic diagnosis vocational education and training for military doctors in grass-roots units, providing new ideas for promoting the deepening development of ultrasonic diagnosis military vocational education in military colleges, so as to promote the reform of military vocational education and training mode, improve the trinity new military personnel training system and enhance the medical service support ability of the troops. Reference | Related Articles | Metrics | Comments（0）

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Correlation analysis between nurses' occupational well-being and practice environment in general hospital in Baoding GONG Youlan, WU Liping, GUO Haitao, YAN Lu, WANG Qian, BAI Lijing, QI Xinrong Journal of Hebei Medical College for Continuing Education    2023, 40 (6): 48-53.   DOI: 10.3969/j.issn.1674-490X.2023.06.007 Abstract （95）      PDF（pc） （445KB）（29）       Knowledge map    Save Objective To investigate the current situation and correlation of nurses' professional happiness and practice environment in general hospital in Baoding city. Methods 1 935 nurses from 7 general hospitals in Baoding were selected to investigate the general situation questionnaire, medical workers' occupational happiness scale and nurse practice environment assessment scale to analyze the current quo of nurses' professional happiness and practice environment, and analyze the correlation between the two. Results Total score of nurse occupational well-being was 80.44±12.11. Total score of nurse practice environment was 70.70±22.34.There was a positive correlation between practice environment and nurse occupational well-being(r=0.614, P<0.01). Conclusion The higher the score of nurse practice environment, the higher the score of nurse's professional happiness. A good nurse practice environment can improve the professional happiness of nurses. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2024, 41 (2): 15-20.   DOI: 10.3969/j.issn.1674-490X.2024.02.003 Abstract （94）      PDF（pc） （458KB）（18）       Knowledge map    Save Communicable disease infection management is an important issue facing our country's public health care, which is closely related to medical quality and the health of doctors and patients. At present, most psychiatric hospitals are weak in attaching importance to its infection prevention and control awareness, compliance with prevention and control measures, and the design of medical zoning and other aspects of infectious disease prevention and control, therefore, the ability of communicable disease infection management needs to be upgraded. So, we reviewed the domestic and international literature and combined with the actual work, to explore the current situation of communicable disease infection management, the factors affecting infection in psychiatric hospitals, and provide rationalization recommendations to improve the capacity of psychiatric hospitals to respond to nosocomial infection problems such as infectious disease events, to do a good job of controlling communicable disease infection in psychiatric hospitals and protect the safety of the patients.-本文引用:陈营营,吴宇飞,张云淑,等.精神专科医院传染病感染管理研究进展［J］.医学研究与教育,2024,41(2):15-20.DOI:10.3969/j.issn.1674-490X.2024.02.003.·临床医学·精神专科医院传染病感染管理研究进展陈营营1,吴宇飞2,张云淑3,郭艳峤4,张红岩4,栗克清3(1.河北大学护理学院,河北 保定 071000;2.河北省第六人民医院护理部,河北 保定 071000;3.河北省第六人民医院精神卫生研究所,河北 保定 071000;4.河北省第六人民医院感控科,河北 保定 071000)摘要:传染病感染管理是中国公共卫生事业面临的重要问题,它与医疗质量以及医患健康密切相关。目前,多数精神专科医院在传染病感染防控的重视程度、感染防控意识、防控措施依从性以及医疗分区设计等多个传染病防治环节均较为薄弱,医院传染病感染管理能力有待提升。通过查阅国内外文献并结合工作实际,探究精神专科医院传染病感染管理现状、感染影响因素,并提出合理化建议以提高精神专科医院应对传染病事件等医院感染问题的能力,切实做好精神专科医院传染病感染控制工作,保障患者安全。关键词:精神专科医院;传染病;影响因素;防控措施DOI:10.3969/j.issn.1674-490X.2024.02.003中图分类号:R74 文献标志码:A 文章编号:1674-490X(2024)02-0015-06Advances on communicable disease infection management in psychiatric hospitalsCHEN Yingying1, WU Yufei2, ZHANG Yunshu3, GUO Yanqiao4, ZHANG Hongyan4, LI Keqing3(1.School of Nursing Sciences, Hebei University, Baoding 071000, China; 2.Department of Nursing, the Sixth People's Hospital of Hebei Province, Baoding 071000, China; 3.Institute of Mental Health, the Sixth People's Hospital of Hebei Province, Baoding 071000, China; 4.Department of Sensory Control, the Sixth People's Hospital of Hebei Province, Baoding 071000, China)Abstract: Communicable disease infection management is an important issue facing our country's public health care, which is closely related to medical quality and the health of doctors and patients. At present, most psychiatric hospitals are weak in attaching importance to its infection prevention and control awareness, compliance with prevention and control measures, and the design of medical zoning and other aspects of infectious disease prevention and control, therefore, the ability of communicable disease infection management needs to be upgraded. So, we reviewed the domestic and international literature and combined with the actual work, to explore the current situation of communicable disease infection management, the factors affecting infection in psychiatric hospitals, and provide rationalization recommendations to improve the capacity of psychiatric hospitals to respond to nosocomial infection problems such as infectious disease events, to do a good job of controlling communicable disease infection in psychiatric hospitals and protect the safety of the patients.-收稿日期:2024-02-26基金项目:2018年河北省政府资助专科能力建设和专科带头人培养项目(361014)第一作者:陈营营(1990—),女,河北沧州人,在读硕士。E-mail: 1219597296@qq.com通信作者:栗克清(1964—),男,河北保定人,教授,硕士,博士生导师,主要从事精神科临床、心理、流行病学研究。E-mail: like2125@sina.com第2期陈营营等:精神专科医院传染病感染管理研究进展2024年 Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2024, 41 (1): 1-8.   DOI: 10.3969/j.issn.1674-490X.2024.01.001 Abstract （92）      PDF（pc） （936KB）（14）       Knowledge map    Save Objective To investigate the effect of Periplaneta americana extract CⅡ-3 in regulating p16INK4a protein in inducing SKOV3 aging. Methods SKOV3 cells were treated with different concentrations of Periplaneta americana extract CⅡ-3,and the effects of CⅡ-3 on the proliferation of SKOV3 cells were detected by CCK-8 assay. The effect of Periplaneta americana extract CⅡ-3 on the colony formation of SKOV3 cells was determined by colony culture experiments. SKOV3 cell cycle changes after CⅡ-3 action were examined with flow cytometry detection. Senescence changes in SKOV3 cells after CⅡ-3 action were determined with SA-β-Gal staining detects. Western Blotting was used to detect the effects of CⅡ-3 on SKOV3 cells phosphorylated p16INK4a protein expression. Results Periplaneta americana extract CⅡ-3 could effectively inhibit the proliferation of SKOV3 cells, and the optimal concentration was 80 μg/mL and an action time was 48 h. The colony formation ratio of SKOV3 cells were reduced after the effect of Periplaneta americana extract CⅡ-3 on SKOV3 cells, the proportion of cells blocked in G0/G1 phase were increased, the proportion of cells in S phase decreased, the percentage of positive cells of SA-β-Gal was increased and the upregulation of the expression of the aging regulatory molecule p16INK4a protein were raised. Conclusion Periplaneta americana extract CⅡ-3 could induce senescence in SKOV3 cells by modulating protein expression of the senescence regulatory molecule p16INK4a. Reference | Related Articles | Metrics | Comments（0）

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Differentical analysis of serum amino acid and acylcarnitine levels in late preterm infants XIANG Jingjing, YANG Dongfei, ZHONG Xiaoyi, WANG Yu Journal of Hebei Medical College for Continuing Education    2023, 40 (6): 12-20.   DOI: 10.3969/j.issn.1674-490X.2023.06.002 Abstract （87）      PDF（pc） （481KB）（36）       Knowledge map    Save Objective To study the relationship between gestational age, birth mass and nutritional support modalities of late preterm infants and their blood amino acid and acylcarnitine levels and provide targeted guidance for the nutritional management of preterm infants at this stage of life. Methods 202 late preterm babies hospitalized from January 2017 to December 2021 were selected for the study. According to the relationship between gestational age and body mass at birth, they were divided into appropriate for gestational age(AGA), small for gestational age(SGA)and large for gestational age(LGA)groups. Nutritional support on the day of sampling was categorised as total parenteral nutrition(TPN), partial parenteral nutrition(PPN)and total enteral nutrition(TEN). Determination and comparison of amino acid and acylcarnitine levels in their peripheral blood were conducted by tandem mass spectrometry techniques Results There were statistically significant differences in the levels of valine, leucine, methionine, phenylalanine, tyrosine, citrulline, and proline between the AGA, SGA, and LGA groups, with the levels of these amino acids being generally higher in the LGA than in the AGA and SGA groups. The differences in acylcarnitine levels were not statistically significant among the three groups.The differences in the levels of glycine, ornithine, leucine, methionine, and citrulline between TPN, PPV, and TEN were all statistically significant, with ornithine, leucine, methionine, and citrulline being relatively low in the TPN approach and glycine being relatively high in the TEN approach.The levels of various short-chain, long-chain and some medium-chain acylcarnitines showed statistically significant differences among the different nutritional modalities, with the highest levels in TEN. Conclusion In late preterm infants, there were differences in the blood amino acid profiles of the AGA, SGA and LGA groups, and SGA could be supplemented with branched-chain amino acids, sulphur-containing amino acids and aromatic amino acids in moderation at an early stage. Blood amino acid and acylcarnitine levels are susceptible to nutritional support modalities. Nutrient ratios should be reasonably adjusted to appropriately increase glycine and carnitine levels in parenteral nutrition solutions, and leucine, methionine, ornithine and glutamine should be added as appropriate in enteral nutrition. Reference | Related Articles | Metrics | Comments（0）

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The current situation and inspiration of cultivating personnel for cleaning and disinfecting digestive endoscopes in China LIN Weina, LUO Fameng, XIA Meiyan, XU Cheng, GAO Nana,YUAN Wei Journal of Hebei Medical College for Continuing Education    2023, 40 (6): 69-74.   DOI: 10.3969/j.issn.1674-490X.2023.06.010 Abstract （86）      PDF（pc） （448KB）（231）       Knowledge map    Save Endoscopic diagnosis and treatment play a crucial role in gastrointestinal diseases, but with the widespread use of endoscopy, the risk of hospital infection caused by improper reprocessing is also increasing. Due to the complex structure of endoscopes, their inability to withstand high temperatures, numerous processes involved in reprocessing, and cumbersome procedures, the reprocessing of flexible endoscopes has become a recognized challenge for medical institutions. Endoscopic cleaning and disinfection personnel play a very important role in the process of endoscopic reprocessing. The ability and quality of this group of people are closely related to the qualification rate of endoscopic reprocessing. However, the qualification rate of endoscopic reprocessing varies in different regions of China. Therefore, this article reviews the composition, continuing education, and job certification of endoscopic cleaning and disinfection personnel in order to provide reference for the cultivation of digestive endoscopic cleaning and disinfection personnel, and further improve the qualification rate of endoscopic reprocessing. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2024, 41 (1): 41-45.   DOI: 10.3969/j.issn.1674-490X.2024.01.006 Abstract （84）      PDF（pc） （424KB）（6）       Knowledge map    Save In Zhang Yuansu's work “Practical Prescriptions for Cold and Heat Patterns of Zangfu Organs: Pangguang”,he introduces the academic concept of treating Pangguang diseases from the perspective of Fei. The author deeply appreciates this viewpoint, believing that the root cause of Pangguang diseases lies in the inadequacy of Feiqi, leading to dysfunction in the downward regulation and water passage functions. This, in turn, hinders the proper Qihua of the Pangguang, resulting in Pangguang pathologies. Therefore, the treatment approach emphasizes Qingfei, Bufei, Runfei, and Xuanfei to ensure smooth Qiji and proper distribution of fluids, thus restoring Pangguang Qihua functions and promoting healing. This artical summarizes the clinical application experiences. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2024, 41 (2): 21-28.   DOI: 10.3969/j.issn.1674-490X.2024.02.004 Abstract （79）      PDF（pc） （485KB）（13）       Knowledge map    Save Breast cancer is the most common malignant tumor in women, which seriously affects the physical and mental health of women. Molecular classification according to pathology, early identification of pathological classification and targeted therapy play a decisive role in ameliorating prognosis of patients. Although pathology is the gold standard, there are some shortcomings, such as the invasiveness of operation, the limitation of sampling and the limitation of testing time. By deeply mining the multi-dimensional features of the image, radiomics quantifies the heterogeneity of the tumor, and uses a non-invasive and simple method to comprehensively evaluate the biological characteristics of the tumor, it has been widely used in the discovery of molecular classification of breast cancer, prediction of LNM, formulation of treatment plan, evaluation of treatment effect, prognosis of patients and so on. In this paper, the application of molecular typing of breast cancer based on MRI radiomics -本文引用:李昊,侯岩,殷小平.基于MRI影像组学在乳腺癌分子分型的研究进展［J］.医学研究与教育,2024,41(2):21-28.DOI:10.3969/j.issn.1674-490X.2024.02.004.·临床医学·基于MRI影像组学在乳腺癌分子分型的研究进展李昊1,2,侯岩1,殷小平1,3(1.河北大学附属医院放射科,河北 保定 071000;2.河北省保定市第一中心医院超声一科,河北 保定 071000;3.河北省炎症相关肿瘤精确影像学重点实验室,河北 保定 071000)摘要:乳腺癌严重影响女性身心健康,是女性最常见的恶性肿瘤,其依据病理不同进行分子分型,早期识别病理分型和靶向治疗是改善患者预后的关键。病理虽为金标准也存在一定不足,如操作的有创性、标本取材的局限性以及检测时间要求的限制性。影像组学通过深度挖掘影像图像多维度特征,将肿瘤的异质性进行量化处理,采用一种无创性、简便的方法对肿瘤的生物学特性进行综合评价,在乳腺癌分子分型的发现、预测淋巴结转移、制订治疗方案、评估治疗效果、判断患者预后等方面已得到广泛应用。现拟基于MRI影像组学特征对乳腺癌分子分型的应用现状进行综述。关键词:乳腺癌;分子分型;影像组学;磁共振成像DOI:10.3969/j.issn.1674-490X.2024.02.004中图分类号:R44 文献标志码:A 文章编号:1674-490X(2024)02-0021-08Advances on MRI radiomics in molecular typing of breast cancerLI Hao1,2, HOU Yan1, YIN Xiaoping1,3(1. Department of Radiology, Affiliated Hospital of Hebei University, Baoding 071000, China; 2. NO.1 Department of Ultrasound, Baoding NO.1 Central Hospital, Baoding 071000, China; 3. Hebei Key Laboratory of Precise Imaging of Inflammation Related Tumors, Baoding 071000, China)Abstract: Breast cancer is the most common malignant tumor in women, which seriously affects the physical and mental health of women. Molecular classification according to pathology, early identification of pathological classification and targeted therapy play a decisive role in ameliorating prognosis of patients. Although pathology is the gold standard, there are some shortcomings, such as the invasiveness of operation, the limitation of sampling and the limitation of testing time. By deeply mining the multi-dimensional features of the image, radiomics quantifies the heterogeneity of the tumor, and uses a non-invasive and simple method to comprehensively evaluate the biological characteristics of the tumor, it has been widely used in the discovery of molecular classification of breast cancer, prediction of LNM, formulation of treatment plan, evaluation of treatment effect, prognosis of patients and so on. In this paper, the application of molecular typing of breast cancer based on MRI radiomics -收稿日期:2023-05-13基金项目:河北省高层次人才资助项目(B20231008)第一作者:李昊(1989—),女,河北保定人,主治医师,硕士,主要从事乳腺影像学诊断。E-mail: vickyhbbd77@126.com通信作者:殷小平(1978—),女,河北保定人,主任医师,博士,博士生导师,主要从事人工智能应用及腹部肿瘤影像学诊断。E-mail: yinxiaoping78@sina.com第2期李昊等:基于MRI影像组学在乳腺癌分子分型的研究进展2024年characteristics is reviewed. Reference | Related Articles | Metrics | Comments（0）

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Brief summary of “Chanbao Qishu” by HOU Tingxiu MENG Hongwei,WANG Linan,WANG Hui,GUAN Zhenjun,YANG Yuejun Journal of Hebei Medical College for Continuing Education    2023, 40 (6): 40-47.   DOI: 10.3969/j.issn.1674-490X.2023.06.006 Abstract （78）      PDF（pc） （513KB）（63）       Knowledge map    Save HOU Tingxiu was a famous gynecologist of traditional Chinese medicine in Baoding in the 1950s.It was found that HOU Tingxiu's compilation of the Chanbao Qishu was a rare literature on fetal and obstetrical diseases. The rare edition of Chanbao Qishu is not widely spread. With rich family heirloom gynecological experience, HOU Tingxiu compiles the essence of the original book, and reinterprets it on the basis of the original book,combined his academic thoughts. The prenatal diseases benefit from applying Liqi and Hexue. The postnatal diseases benefit from using Shenghua Tang. It is of great value to study Chanbao Qishu and HOU Tingxiu's experience in the treatment of fetal and obstetrical diseases. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2024, 41 (2): 71-80.   DOI: 10.3969/j.issn.1674-490X.2024.02.010 Abstract （76）      PDF（pc） （698KB）（16）       Knowledge map    Save Objective To analysis the evolution of the concept of health literacy of chronic disease and clarify its connotation. Methods We comprehensively searched for studies related to health literacy of chronic diseases from databases, including CNKI, Wanfang Data, CBM, VIP, PubMed, Web of Science, ProQuest, Springer Link and Elsevier Science Direct. Relevant papers from the inception of databases up to July 2023 were selected. Rodgers evolutionary method of concept analysis was applied. Results A total of 47 articles were included. Ultimately, the concept attributes of health literacy of chronic disease were knowledge of chronic diseases, treatment adherence, actively accessing and understanding health information, ability to interact in face-to-face and online, health decision-making. Antecedents include demographic factors, disease factors, family and social support, -本文引用:陈爽,李艳玲.慢性病健康素养的概念分析［J］.医学研究与教育,2024,41(2):71-80.DOI:10.3969/j.issn.1674-490X.2024.02.010.·护理学·慢性病健康素养的概念分析陈爽1,2,李艳玲2(1.河北大学护理学院,河北 保定 071000;2. 河北大学附属医院,河北 保定 071000)摘要:目的 梳理慢性病健康素养的概念演变并阐明其概念内涵。方法 全面检索中国期刊全文数据库、万方数据知识服务平台、中国生物医学文献数据库、维普数据库、PubMed、Web of Science、ProQuest、Springer Link、Elsevier Science Direct数据库中与慢性病健康素养相关的研究,检索时限为建库至2023年7月。采用Rodgers演化概念分析法进行分析。结果 共47篇文献纳入概念分析。最终归纳出慢性病健康素养的概念属性分别是慢性病防治知识、治疗依从性、主动获取和理解健康信息、线上及线下交互能力、健康决策;前因包括人口学因素、疾病因素、家庭和社会支持、心理因素及组织因素;后果包括自我管理行为、自我效能、疾病控制情况、健康赋权及健康相关生活质量。结论 通过概念分析明确了慢性病背景下健康素养的概念内涵,随着相关研究的不断涌现,这一概念内涵还需要进一步探索与演变。关键词:慢性病;健康素养;概念分析;护理DOI:10.3969/j.issn.1674-490X.2024.02.010中图分类号:R473.1 文献标志码:A 文章编号:1674-490X(2024)02-0071-10Concept analysis of health literacy of chronic diseasesCHEN Shuang1,2,LI Yanling2(1. College of Nursing Sciences,Hebei University,Baoding 071000,China;2. Affiliated Hospital of Hebei University,Baoding 071000,China)Abstract: Objective To analysis the evolution of the concept of health literacy of chronic disease and clarify its connotation. Methods We comprehensively searched for studies related to health literacy of chronic diseases from databases, including CNKI, Wanfang Data, CBM, VIP, PubMed, Web of Science, ProQuest, Springer Link and Elsevier Science Direct. Relevant papers from the inception of databases up to July 2023 were selected. Rodgers evolutionary method of concept analysis was applied. Results A total of 47 articles were included. Ultimately, the concept attributes of health literacy of chronic disease were knowledge of chronic diseases, treatment adherence, actively accessing and understanding health information, ability to interact in face-to-face and online, health decision-making. Antecedents include demographic factors, disease factors, family and social support, -收稿日期:2023-09-07第一作者:陈爽(1993—),女,河北保定人,主管护师,在读硕士,主要从事慢性病护理。E-mail: chenshuang1629@163.com通信作者:李艳玲(1978—),女,河北保定人,主任护师,在读博士,硕士生导师,主要从事老年护理和护理管理研究。E-mail: xsliyanling@163.com第2期陈爽等:慢性病健康素养的概念分析2024年psychological factors, and organizational factors. Consequences include self-management behaviors, self-efficacy, disease control, health empowerment, and health-related quality of life. Conclusion The conceptual connotation of health literacy in the context of chronic diseases was clarified through concept analysis. In the future,this concept will need to be explored and evolved as relevant studies continue to emerge. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2024, 41 (2): 48-55.   DOI: 10.3969/j.issn.1674-490X.2024.02.007 Abstract （75）      PDF（pc） （530KB）（7）       Knowledge map    Save Since TCM classics contains a large amount of Confucian and Taoist thoughts,Confucianism and Taoism are of great value in interpreting them. This paper takes LIU Wansu's interpretation of Suwen and the creation of the theory of Huore as an example to explore the way of the interpretation of TCM classics by Confucianism and Taoism. The results show that it is the cornerstone of the theory of Huore to investigate the principle of things and interpret by image taking and analogy, the Wuxing and the images they form are the basis for the interpretation of the Liuqi Huahuo. Confucianism and Taoism are combined to explain TCM theory, Shangshanruoshui with Xiayuruhuo is the basic principle of LIU Wansu's interpretation of Wuzhihuahuo. Since the Gewu is only a general understanding of things, it is not necessarily true knowledge to apply the Confucian and Taoist methods to understand things in the medical field. LIU Wansu finally combined with the clinical experience to verify the theory of Huore. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2024, 41 (2): 1-8.   DOI: 10.3969/j.issn.1674-490X.2024.02.001 Abstract （72）      PDF（pc） （1090KB）（164）       Knowledge map    Save Objective To investigate the feasibility of speckle tracking technique in evaluating the improvement of-本文引用:毕亮亮,赵红梅,李成,等.斑点追踪技术在达格列净改善蒽环类药物所致小鼠心脏毒性中的应用研究［J］.医学研究与教育,2024,41(2):1-8.DOI:10.3969/j.issn.1674-490X.2024.02.001.·基础医学·斑点追踪技术在达格列净改善蒽环类药物所致小鼠心脏毒性中的应用研究毕亮亮1,赵红梅2,李成3,李瑞4,尚丽娜1,邸桂新1,赵金惠1(1.河北大学附属医院超声诊断科,河北 保定 071000;2.河北大学附属医院老年医学科,河北 保定 071000;3.河北大学附属医院体检中心,河北 保定 071000;4.河北大学附属医院产科,河北 保定 071000)摘要:目的 探讨斑点追踪技术在评估达格列净改善蒽环类药物所致小鼠心脏毒性的可行性。方法 将BALB/c雄性小鼠随机分为对照组、表柔比星组和达格列净干预组。达格列净在表柔比星用药前连续给药3 d,然后每间隔1 d给药1次,持续3周(给予10 mg/kg达格列净,灌胃)。表柔比星(3 mg/kg,腹腔注射)或等体积0.9%氯化钠溶液每4天注射1次,持续3周。分别于基线、第3周期化疗后和最后一周期化疗后1 d行常规超声心动图检查和基于斑点追踪技术左心室整体纵向应变(global longitudinal strain,GLS)测量。实验结束后,通过组织学分析评估心肌损伤。结果 与对照组和达格列净干预组比较,表柔比星组表现出明显的心肌细胞结构异常,胶原蛋白含量和心肌细胞凋亡百分比增高。心脏功能方面,表柔比星组在第3周期注射后GLS显著降低(P<0.05),并且随着累积剂量的增加,GLS持续下降(P<0.05);达格列净干预组GLS只在最后一周期化疗结束后表现为轻微减低,但差异无统计学意义(P>0.05)。此外,GLS与心肌病理损伤表现出良好的相关性,且与胶原蛋白含量相关性最高(rs=-0.637,P<0.001)。结论 达格列净干预治疗后可明显改善化疗小鼠的心脏损伤;GLS在评估接受心脏保护性药物后的心功能改善方面是可行的。关键词:斑点追踪;达格列净;蒽环类药物;心脏毒性DOI:10.3969/j.issn.1674-490X.2024.02.001中图分类号:R969 文献标志码:A 文章编号:1674-490X(2024)02-0001-08Study on dapagliflozin in improving cardiotoxicity induced by anthracyclines in mice with speckle tracking techniqueBI Liangliang1, ZHAO Hongmei2, LI Cheng3, LI Rui4, SHANG Lina1, DI Guixin1, ZHAO Jinhui1(1.Department of Ultrasound Diagnosis, Affiliated Hospital of Hebei University, Baoding 071000, China; 2.Department of Geriatrics, Affiliated Hospital of Hebei University, Baoding 071000, China; 3.Physical Examination Center, Affiliated Hospital of Hebei University, Baoding 071000, China; 4.Department of Obstetrics, Affiliated Hospital of Hebei University, Baoding 071000, China)Abstract: Objective To investigate the feasibility of speckle tracking technique in evaluating the improvement of-收稿日期:2023-11-23基金项目:河北省科技厅基金项目(19277761D);河北省医学科学研究重点课题(20180725)第一作者:毕亮亮(1984—),女,河北保定人,主治医师,博士,主要从事心血管疾病超声诊断。E-mail:biliangliang111@126.com 通信作者:赵红梅(1981—),女,河北保定人,副主任医师,硕士,主要从事心血管疾病临床诊治。E-mail:zhaohongmei_20062007@126.com 第2期毕亮亮等:斑点追踪技术在达格列净改善蒽环类药物所致小鼠心脏毒性中的应用研究2024年cardiotoxicity induced by anthracyclines with dapagliflozin. Methods Male BALB/c mice were randomly divided into normal control group, epirubicin group and epirubicin plus dapagliflozin group. Dapagliflozin were administered at three consecutive days before epirubicin treatment, followed by once every other day for 3 weeks(10 mg/kg, p.o.). Epirubicin(3 mg/kg, i.p.)or an equal volume of 0.9% sodium chloride solution were injected every 4 days for 3 weeks. Conventional echocardiography and measurement of left ventricular global longitudinal strain(GLS)based on speckle tracking technique were performed at baseline, one day after the third Epi dosage and one day after the last chemotherapy. Myocardial damage were evaluated by histological analysis at the end of experiment. Results Compared with control group and epirubicin plus dapagliflozin group, epirubicin group showed significant abnormalities in myocardial cell structure, and an increase in collagen content and percentage of myocardial cell apoptosis. In terms of cardiac function, GLS decreased significantly after the third injection in epirubicin group(P<0.05), and GLS continued to decrease with increasing cumulative dose(P<0.05). GLS only showed slight decrease in epirubicin plus dapagliflozin group after the last chemotherapy, but this difference was not statistically significant(P>0.05). In addition, there was a good correlation between GLS and myocardial pathological damage, with collagen content showing the highest correlation(rs=-0.637,P<0.001). Conclusion Dapagliflozin can significantly improve the heart damage caused by epirubicin in the mouse model. GLS is feasible for evaluating heart function improvement after receiving cardioprotective drugs. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2024, 41 (4): 74-80.   DOI: 10.3969/j.issn.1674-490X.2024.04.009 Abstract （71）      PDF（pc） （621KB）（16）       Knowledge map    Save Objective To systematically review relevant literatures in the field of orthopedic teaching research in the past decade, analyze the current research status and hotspots, and provide reference for the cultivation of high-quality orthopedic teaching talents and future orthopedic teaching reforms. Methods The bibliometric research method was used to analyze the annual publication volume, authors, affiliations, published journals, research topics, and fund support of literatures related to orthopedic teaching and research collected on China National Knowledge Infrastructure, Wanfang Data Knowledge Service Platform, and Weipu Chinese Science and Technology Periodical Database from January 1, 2014 to December 31, 2023. Results A total of 1 569 literatures were included in the study, and the overall annual publication volume showed a fluctuating upward trend. The high-publication authors were mainly LIU Rui, GUAN Jianzhong, ZHEN Zhilong, and so on. The high-publication affiliations included Affiliated Hospital of Inner Mongolia Medical University, First Affiliated Hospital of Bengbu Medical College, Affiliated Chaoyang Hospital of Capital Medical University, and so on. The studies focused on orthopedic clinical teaching, problem-based learning(PBL)/clinical case-based learning(CBL), 3D printing, orthopedic nursing teaching, standardized training for resident physicians, flipped classrooms, and so on. Conclusions In the past decade, the annual publication volume of relevant literatures in the field of orthopedic teaching and research has shown an overall fluctuating upward trend. The high-publication authors are relatively concentrated, and the main publishing affiliations are affiliated hospitals of various medical colleges. However, there is a lack of close cooperation between different affiliations. Based on the focus on traditional teaching methods, research hotspots should further focus on the transformation of orthopedic teaching methods driven by advanced technology. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2024, 41 (3): 18-24.   DOI: 10.3969/j.issn.1674-490X.2024.03.003 Abstract （70）      PDF（pc） （701KB）（30）       Knowledge map    Save Coronary heart disease is the most common cause of death in the elderly. The incidence of frailty in elderly patients is significantly increased. Frailty assessment can well predict the prognosis of elderly patients with coronary heart disease. However, the mechanism of frailty leading to poor prognosis of coronary heart disease is not very clear. Studies have shown that intestinal flora may play an important role in patients with frailty and coronary heart disease. In recent years, due to the advancement of gene sequencing technology, the correlation between intestinal flora and frailty in the elderly has become clearer. The main purposes of this review are to explain the important role of intestinal flora in the occurrence and development of patients with frailty and coronary heart disease by analyzing the relationship between intestinal flora and frailty through early intervention of intestinal flora in patients with frailty to achieve the purpose of preventing adverse cardiovascular events and in order to provide a theoretical basis for clinical secondary prevention of patients with coronary heart disease. Reference | Related Articles | Metrics | Comments（0）

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Application of Fengyao based on the theory of Qihua from ancient times to modern times WANG Tao, LIU Yawei, ZHANG Lan, WANG Ying, SONG Lei Journal of Hebei Medical College for Continuing Education    2023, 40 (6): 34-39.   DOI: 10.3969/j.issn.1674-490X.2023.06.005 Abstract （68）      PDF（pc） （472KB）（52）       Knowledge map    Save Fengyao has been widely used by doctors in the past dynasties, and many schools have different application characteristics.From “Neijing” to “Shanghanzabinglun”and to the “Yishuixuepai”in the Jin and Yuan Dynasties, as well as many schools, to the “Wenbingxuepai”in the Ming and Qing Dynasties, as well as other schools,they have different opinions on Fengyao,but their theoretical origins come down in one continuous line.This paper discusses the application characteristics of Fengyao from the perspective of human body Qihua theory,to show it is passed from ancient times to modern times,although the history of the application of Fenyao has a long history.It embodies the theoretical characteristics of traditional Chinese medicine. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2024, 41 (2): 29-41.   DOI: 10.3969/j.issn.1674-490X.2024.02.005 Abstract （66）      PDF（pc） （620KB）（12）       Knowledge map    Save Cognitive impairment is the most important clinical manifestation of cerebral small vessel disease. The main clinical manifestation of cerebral small vessel disease is the decline of memory and attention, executive function, information processing speed and language fluency, it's a very common neurological disorder. The early symptoms of cerebral small vessel disease are not typical and easy to be diagnosed. The late stage often affects the quality of life of cerebral small vessel disease patients. The article summarizes the pathogenesis of small cerebral vascular disease and the relevant imaging examination methods, it is expected to provide theoretical basis for the research and treatment of cognitive impairment, delaying the progress of cognitive impairment and improving the quality of life of the elderly. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2024, 41 (3): 1-7.   DOI: 10.3969/j.issn.1674-490X.2024.03.001 Abstract （65）      PDF（pc） （844KB）（28）       Knowledge map    Save Objective To investigate the protective effect of hydroxylsafflor yellow A(HSYA)on the mice with experimental autoimmune hepatitis using concanavalin A Con A-induced liver injury mouse model. Methods A total of 36 BALB/c mice were randomly divided into Sham group, Con A group, HSYA low-dose group(5 mg/kg), HSYA medium-dose group(10 mg/kg), HSYA high-dose group(20 mg/kg)and Sham+HSYA high-dose group(20 mg/kg), with 6 mice in each group. Mice in each group were weighed and the weight was recorded. Then, the mice were pretreated with HSYA through intraperitoneal injection for three days. The experimental autoimmune mouse model was made by tail intravenous injection of Con A 12 hours before we killed the mice. Mice were killed by carbon dioxide inhalation ultimately and we took materials for the next experimental operations. The AST and ALT levels of each group were detected with automatic biochemical analyzer and compared between groups. The liver tissue were stained with hematoxylin-eosin, we observed the pathological changes of liver tissue under a microscope. The level of IL-17, IL-10 and TNF-α in plasma were measured with enzyme linked immunosorbent assay. Results Compared with the Sham group, Plasma level of TNF-α, IL-17, IL-10 and AST, ALT in mice were significantly increased at 12 hours after Con A treatment(P<0.05),meanwhile a lot of necrotic liver cells could be seen under the microscope. Compared with the Con A group, plasma level of inflammatory factors and transaminase in HSYA(10 mg/kg and 20 mg/kg)group were markedly decreased, meanwhile a few of necrotic liver cells could be seen under the microscope. Conclusion Con A could induce liver injury in mice successfully, HSYA has a protective effect on the mice with experimental autoimmune hepatitis. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2024, 41 (1): 27-33.   DOI: 10.3969/j.issn.1674-490X.2024.01.004 Abstract （64）      PDF（pc） （463KB）（24）       Knowledge map    Save Acute myocardial infarction, as the most severe condition of coronary artery disease, is often accompanied by severe chest pain, which not only reduces the patient's treatment compliance, but also worsens the condition by increasing myocardial oxygen consumption, increasing cardiac load, and inducing coronary vasospasm. Therefore, timely intervention of severe chest pain is essential in the treatment of acute myocardial infarction. This article reviews the mechanism of pain in acute myocardial infarction, the use of opioids and non-steroidal anti-inflammatory drugs in acute myocardial infarction. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2024, 41 (2): 42-47.   DOI: 10.3969/j.issn.1674-490X.2024.02.006 Abstract （60）      PDF（pc） （509KB）（12）       Knowledge map    Save Yishui School, as a unique medical school in the history of traditional Chinese medicine, has greatly enriched the theoretical connotation of traditional Chinese medicine with its dialectical views on the organs, emphasis on the spleen and stomach, the theory of introducing meridians and promoting circulation, and the theory of ascending, descending, floating, and sinking. LI Fuhai is a disciple of Professor Lu Zhizheng, a master of traditional Chinese medicine. This article aims to discuss three medical cases encountered by Dr.LI during the process of clinical practices, analyzes the application and inspiration of the theory of Shengjiang in Yishui School, and provide ideas for further inheriting the ideas of Yishui School, innovating treatment methods and improving clinical efficacy. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2024, 41 (2): 63-70.   DOI: 10.3969/j.issn.1674-490X.2024.02.009 Abstract （59）      PDF（pc） （488KB）（12）       Knowledge map    Save The information needs of caregivers are strongly associated with the treatment outcomes and quality of life for patients. Nevertheless, the unfulfilled information needs of the majority of caregivers of stroke patients not only impact the prognosis and health outcomes of the patients, but also amplify the uncertainty that caregivers face when navigating unforeseen circumstances, making them “invisible patients”. This study reviews the content, influencing factors, supporting forms and assessment tools of information needs of caregivers of stroke patients. It's expected to provide a basis for more professional and targeted information support for caregivers. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2024, 41 (4): 38-52.   DOI: 10.3969/j.issn.1674-490X.2024.04.006 Abstract （59）      PDF（pc） （767KB）（9）       Knowledge map    Save LIU Wansu integrated scientific principles into his theories, drawing from “HUANGDI NEIJING” and “SHANGHAN LUN”. He proposed the theory of “HUORE” with “Zangfu Yunqi”, “Zangfu Shuihuo”, “Liuqi Jie Huahuo ”, “Wuzhi Huahuo”and “Shanghan Ji Rebing”. Additionally, he supplemented the pathogenesis of “Zaoqi” and expanded on the theory of internal and external diseases. For externally induced fever, he believed that the main pathogenesis was Xuanfu Yuzhi, Yangqi Fuyu, and Yangre Yujie. Treatment involved using cold and cool drugs to clear heat and reduce fire. LIU Wansu's approach to treating Rebing became foundational for later developments in this field. Influenced by Liu Wansu's work, there were many academic inheritors who formed an important school in traditional Chinese medicine known as the Hejian school. This influence also extended to ZHANG Congzheng, ZHU Danxi, LI Dongyuan who put forward new theories that promoted the development of what is now known as the Hejian school. The combination of ZHANG Congzheng's theory of Gongxie, ZHU Danxi's theory of Yang Youyu Yin Buzu along with LIU Wansu's theory constituted the main characteristics of this school which set it apart from other academic schools within traditional Chinese medicine. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2024, 41 (3): 71-75.   DOI: 10.3969/j.issn.1674-490X.2024.03.010 Abstract （58）      PDF（pc） （397KB）（19）       Knowledge map    Save Objective To explore the application effect of PDCA cycle management in protective restraint of critically ill patients. Methods A total of 252 patients of Emergency Intensive Care Unit admitted to our hospital from November 27, 2022 to June 23, 2023 were divided into control group and study group according to computer random allocation method, with 126 cases in each group. The control group was given routine protective restraint nursing. Based on the general protective restraint nursing, the study group adopted the protective restraint nursing under the PDCA cycle management model. The appropriate rate of restraint relaxation, the correct rate of restraint limb position,the normal rate of skin at the restraint site and the good blood circulation rate of limb extremities were compared between the two groups. Results The suitable rate of restraint relaxation, the correct rate of restraint limb position, the normal rate of skin at the restraint site, and the good blood circulation rate of limb extremities in the study group were higher than those in the control group, and the differences were statistically significant(P<0.05). Conclusion In protective restraint nursing of critically ill patients, PDCA cycle management mode can effectively improve the suitable rate of restraint relaxation, the correct rate of restraint limb position, the normal rate of skin in the restraint site, and the good blood circulation rate of limb extremities. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2024, 41 (3): 40-45.   DOI: 10.3969/j.issn.1674-490X.2024.03.006 Abstract （58）      PDF（pc） （467KB）（5）       Knowledge map    Save Carcinomatous polyarthritis is one of the easily neglected clinical complications of malignancy. With the continuous progress of modern medicine, cancerous polyarthritis has received more and more attention. In clinical practice, western medicine has its limitations and poor efficacy in the treatment of cancerous polyarthritis, but Chinese medicine has achieved good results in the understanding and treatment of this disease due to its unique advantages of “holistic concept and evidence-based treatment”. We believe that the pathogenesis of cancerous polyarthritis is closely related to the accumulation of cancerous toxins, external exposure to evil spirits and physical factors, and that the basic pathogenesis of the disease is “Yangxu xiecou, Tanyu hujie”. The treatment can achieve satisfactory results, and a effective case were attached to prove it. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2024, 41 (4): 53-59.   DOI: 10.3969/j.issn.1674-490X.2024.04.007 Abstract （55）      PDF（pc） （469KB）（11）       Knowledge map    Save By combing through and summarizing the current state of nursing death education development at home and abroad, this paper aims to build on this and explore instructional models for nursing death education appropriate for our country. A more systematic and scientific curriculum for post-mortem education in nursing is recommended, with enhanced stereo, constructive, and experiential practical application, and assessment of teaching practice needs based on the characteristics of nursing students. We will enhance the training and construction of death education teachers, and implement curriculum evaluation by combining quantity and quality, so as to promote the effective implementation of our education in nursing death. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2024, 41 (4): 1-7.   DOI: 10.3969/j.issn.1674-490X.2024.04.001 Abstract （55）      PDF（pc） （775KB）（16）       Knowledge map    Save Objective To observe the effect of oleanolic acid on senescent Leydig cells and the regulation of EGF and EGFR. Methods Primary cultured rat Leydig cells were divided into normal group, model group and oleanolic acid group. The model group and the neat fruit acid group were treated with H2O2(300 μmol/L)and FeSO4(100 μmol/L)daily for 2 h for 4 d. Thereafter, the normal and model groups were cultured in DMEM/F12 medium for 3 d, and the oleanolic acid group was cultured in DMEM/F12 medium with a final concentration of 20 μmol/L. Testosterone secretion was measured by ELISA, proliferation by immunofluorescence staining by BrdU, apoptosis by DAPI staining, and EGF and EGFR mRNA expression by qRT-PCR. Results Compared with the normal group, the testosterone secretion level, cell proliferation rate, EGF and EGFR mRNA expression level were significantly decreased(P<0.05), and the apoptosis rate was significantly increased(P<0.05). Oleanolic acid significantly inhibited apoptosis in the model group(P<0.05)and significantly increased testosterone secretion, cell proliferation levels, and EGF and EGFR mRNA expression levels(P<0.05). Conclusion Oleanolic acid can promote testosterone secretion and cell proliferation and inhibit cell apoptosis, and its mechanism may be related to the regulation of EGF and EGFR mRNA expression. Reference | Related Articles | Metrics | Comments（0）

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Journal of Hebei Medical College for Continuing Education    2024, 41 (4): 15-20.   DOI: 10.3969/j.issn.1674-490X.2024.04.003 Abstract （54）      PDF（pc） （444KB）（15）       Knowledge map    Save Cerebral small vessel disease(CSVD)is a wide range of cerebrovascular diseases with a variety of causes, which is the most common cause of vascular dementia. With increasing age, the prevalence of CSVD also increases, affecting the quality of life of the elderly population. With the continuous exploration and application of traditional magnetic resonance imaging technology, functional magnetic resonance technology has been rapidly developed, and it is expected to provide more possibilities for the early diagnosis of CSVD and the relationship between CSVD and vascular cognitive impairment. This article reviews the application and research advances of multimodal functional magnetic resonance imaging in observing the relationship between CSVD and vascular cognitive impairment in order to provide evidence for the clinical diagnosis of CSVD from the perspective of imaging. Reference | Related Articles | Metrics | Comments（0）