替罗非班对急性脑梗死机械取栓患者氧化应激水平及神经功能的影响

doi:10.3969/j.issn.1674-490X.2021.05.004

摘要/Abstract

摘要： 目的探讨替罗非班对急性脑梗死机械取栓患者氧化应激水平和神经功能的影响。方法选取2019年9月至2020年9月收治的88例急性脑梗死患者为研究对象,所有患者按照治疗方法的不同分为对照组及观察组,每组44例,2组患者均行机械取栓,观察组同时应用替罗非班;比较2组患者术前、术后36 h、出院前的氧化应激因子血清C反应蛋白、丙二醛、超氧化物歧化酶、谷胱甘肽过氧化物酶水平、神经功能缺损评分、泛素羧基末端水解酶-1、神经胶质原纤维酸性蛋白、脑源性神经营养因子及血管再通率。结果与术前比较,术后36 h和出院前观察组患者的各项指标均显著优于对照组(P<0.05);与术后36 h比较,出院前2组患者的氧化应激因子水平与神经功能指标均有显著改善,且观察组患者的各项指标显著优于对照组(P<0.05);观察组患者的术后血管总再通率(95.45%)显著高于对照组(72.73%)。结论替罗非班可有效改善急性脑梗死机械取栓患者高氧化应激状态,降低患者神经功能缺损。

关键词: 替罗非班, 急性脑梗死, 氧化应激, 神经功能

Abstract: Objective To investigate the effect of tirofiban on oxidative stress and neurological function in patients with acute cerebral infarction undergoing mechanical thrombectomy.Methods 88 patients with acute cerebral infarction from September 2019 to September 2020 were selected as the research objects.All patients were divided into control group and observation group according to different treatment methods, with 44 cases in each group.Mechanical embolectomy was performed in both groups, and tirofiban was applied in the observation group at the same time.The levels of CRP, MDA, SOD, GSH PX and neurological function of the two groups before operation, 36 hours after operation and before discharge were compared NIHSS, UCH-L1, GFAP, BDNF and recanalization rate were measured.Results Compared with before operation, the indexes of the observation group were significantly better than those of the control group at 36h after operation and before discharge(P<0.05), compared with 36h after operation, the levels of oxidative stress factors and neurological function indexes of the two groups before discharge were significantly improved, and the indexes of the observation group were significantlybetter than those of the control group(P<0.05), the postoperative recanalization rate of the observation group(95.45%)was significantly higher than that of the control group(72.73%).Conclusion Tirofiban can effectively improve the high oxidative stress state and reduce the neurological deficit in patients with acute cerebral infarction.

Key words: tirofiban, acute cerebral infarction, oxidative stress, neurological function

中图分类号:

庄建港. 替罗非班对急性脑梗死机械取栓患者氧化应激水平及神经功能的影响[J]. 医学研究与教育, 2021, 38(5): 20-25.

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