内质网应激在女性生殖系统和乳腺恶性肿瘤治疗中的研究进展

doi:10.3969/j.issn.1674-490X.2026.02.001

摘要/Abstract

摘要： 内质网应激及其触发的未折叠蛋白反应在肿瘤的发生、发展和治疗抵抗中发挥着关键的双向调控作用。该信号通路不仅通过调节免疫细胞功能与免疫原性细胞死亡重塑肿瘤免疫微环境,而且也成为重要的治疗靶点。卵巢癌、宫颈癌、子宫内膜癌及乳腺癌的发病率和病死率高,分子机制复杂且治疗挑战大,深入探究其共性与特性的病理机制至关重要。系统概述内质网应激在上述肿瘤中的复杂作用,重点聚焦其与肿瘤免疫微环境的相互作用以及相关药物研发进展,旨在为开发新型抗肿瘤方案提供理论基础。

关键词: 内质网应激, 未折叠蛋白反应, 妇科恶性肿瘤, 乳腺癌, 肿瘤免疫微环境

Abstract: Endoplasmic reticulum stress and the unfolded protein response it induces play a critical bidirectional regulatory role in tumor occurrence, progression, and treatment resistance. This signaling pathway not only remodels the tumor immune microenvironment by regulating immune cell function and immunogenic cell death, but is also gaining attention as an important therapeutic target. Ovarian cancer, cervical cancer, endometrial cancer, and breast cancer have high incidence and mortality rates, and their molecular mechanisms are complex and difficult to treat.Therefore, it is crucial to deeply explore the common and specific pathological mechanisms.This review systematically outlines the complex roles of endoplasmic reticulum stress in the aforementioned tumors, focusing particularly on interactions with the tumor immune microenvironment and advances in related drug development, aiming to provide a theoretical foundation for the development of new anti-tumor strategies.

Key words: endoplasmic reticulum stress, unfolded protein response, gynecologic malignant tumors, breast cancer, tumor immune microenvironment

中图分类号:

R733

白志圆,周玥. 内质网应激在女性生殖系统和乳腺恶性肿瘤治疗中的研究进展[J]. 医学研究与教育, 2026, 43(2): 1-11.

BAI Zhiyuan, ZHOU Yue. Advances on endoplasmic reticulum stress in the treatment of female reproductive system and breast malignant tumors[J]. Journal of Hebei Medical College for Continuing Education, 2026, 43(2): 1-11.

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