导痰汤合四苓散药食同源方干预肥胖的研究进展与现实意义

doi:10.3969/j.issn.1674-490X.2026.05.006

医学研究与教育 ›› 2026, Vol. 43 ›› Issue (5): 47-54.DOI: 10.3969/j.issn.1674-490X.2026.05.006

• 中医药学 • 上一篇

导痰汤合四苓散药食同源方干预肥胖的研究进展与现实意义

李雨¹,李佳²,葛少钦³

1.河北大学附属医院生殖医学科, 河北保定 071000;
2.药都严选健康产业集团(安国)有限公司, 药都严选大健康产业研究院, 河北保定 071200;
3.河北大学中医学院, 河北保定 071002

收稿日期:2026-07-28 发布日期:2026-10-21
通讯作者: 葛少钦(1967—),男,河北保定人,教授,博士生导师,主要从事中西医结合肥胖/生殖基础研究与转化。E-mail: gesq67@163.com
作者简介:李雨(1998—),女,河北容城人,在读博士,主要从事中西医结合肥胖/生殖基础研究。 E-mail: liliy0709@163.com
基金资助:
河北省自然科学基金(H22022201069);河北省科技厅港澳台科技合作专项(25292502D)

Developments and practical significance of Daotan Tang He Siling San in the intervention of obesity

Li Yu¹, Li Jia², Ge Shaoqin³

Anguo)Co., Ltd., Baoding 071200, China; 3.College of Chinese Medicine, Hebei University, Baoding 071002, China

Received:2026-07-28 Published:2026-10-21

摘要/Abstract

摘要： 肥胖及其引发的代谢综合征、生殖损伤已成为全球性的公共卫生威胁。针对当下全民减脂、全民健康的宗旨,开展经典名方“导痰汤合四苓散”的研究与开发具有重要的现实意义。基于协同配伍理论,合理运用国家公布的药食同源中药替代原方中的非药食同源/毒性成分,对经典方进行化裁改良,构建了导痰汤合四苓散药食同源方(the Daotan Siling Decoction medicine and food homologous prescription,F-M DTSLD),并开展了大鼠药效学研究,证实F-M DTSLD在减轻体质量、改善糖脂代谢紊乱、抑制慢性炎症及逆转肥胖导致的雄性生殖损伤(改善精子质量与睾丸超微结构)等方面具有显著的生物学效应。本综述系统梳理了F-M DTSLD的研究进展及该方的研究意义与展望,旨在打造能够融入大众日常餐饮的药食同源健康产品,为推进全民科学减重、构建慢病主动健康管理模式提供坚实的理论支撑。

关键词: 导痰汤合四苓散, 药食同源方, 干预, 肥胖

Abstract: Obesity and its associated metabolic syndrome and reproductive damage have become a global public health challenge. In view of the current purpose of national fat reduction and national health, it is of great practical significance to carry out the research and development of the classic prescription “Daotan Tang He Siling San”.Based on the theory of synergistic compatibility, our laboratory rationally used the medicine and food homologous Chinese medicine published by the state to replace the non-medicine and food homologous/toxic components in the original prescription, and modified the classical prescription to construct the Daotan Siling Decoction medicine and food homologous prescription( F-M DTSLD ), and carried out pharmacodynamic studies in rats. It was confirmed that F-M DTSLD had significant biological effects in reducing body weight, improving glucose and lipid metabolism disorders, inhibiting chronic inflammation, and reversing male reproductive damage caused by obesity(improving sperm quality and testicular ultrastructure). This review systematically reviews the research progress of F-M DTSLD and the research significance and prospects of F-M DTSLD, aiming to create a health product that can be integrated into the daily catering of the public, and provide solid theoretical support for promoting the scientific weight loss of the whole people and constructing the active health management model of chronic diseases.

Key words: Daotan Tang He Siling San, medicine and food homologous Fang, intervention, obesity

中图分类号:

李雨,李佳,葛少钦. 导痰汤合四苓散药食同源方干预肥胖的研究进展与现实意义[J]. 医学研究与教育, 2026, 43(5): 47-54.

Li Yu, Li Jia, Ge Shaoqin. Developments and practical significance of Daotan Tang He Siling San in the intervention of obesity[J]. Journal of Hebei Medical College for Continuing Education, 2026, 43(5): 47-54.

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导痰汤合四苓散药食同源方干预肥胖的研究进展与现实意义

Developments and practical significance of Daotan Tang He Siling San in the intervention of obesity

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