干细胞在心肌再生中的研究进展

doi:10.3969/j.issn.1674-490X.2011.04.017

摘要/Abstract

摘要： 在中国,心肌梗死、心衰等疾患的发病率正逐年上升,而传统的以药物、介入、手术为主的治疗手段只能改善心脏的血液供应,对坏死心肌无再生修复功能.动物及临床实验证实,干细胞可再生心肌,具有减少梗死面积、提高射血分数的作用.现就可再生心肌干细胞作一综述.

中图分类号:

R542.2

瞿海龙,麻晓静,张冰,梁璐. 干细胞在心肌再生中的研究进展[J]. 医学研究与教育, 2011, 28(4): 61-65.

[1] Hakuno Daihiko, Fukuda Keiichi, Makino Shinji, Konishi Fusako, Tomita Yuichi, Manabe Tomohiro, Suzuki Yusuke, Umezawa Akihiro, Ogawa Satoshi. Bone marrow-derived regenerated cardiomyocytes (CMG Cells) express functional adrenergic and muscarinic receptors. [J]. Circulation: An Official Journal of the American Heart Association 2002, 3(3).
[2] Bodo-Eckehard Strauer, Gudrun Ott, Christine Maria Schannwell, Michael Brehm. Bone marrow cells to improve ventricular function [J]. Heart 2009, 2(2).
[3] ORLIC D, KAJSTURA J, CHIMENTI S. Bone marrow cells regenerate infarcted myocardium [J]. Nature 2001, 410(6829).
[4] Ledda Mario, Barile Lucio, Chimenti Isotta, De Carlo Flavia, Forte Elvira, Ionta Vittoria, Giuliani Livio, D'Emilia Enrico, Frati Giacomo, Miraldi Fabio, Pozzi Deleana, Messina Elisa, Grimaldi Settimio, Giacomello Alessandro, Lisi Antonella. Differentiation of human adult cardiac stem cells exposed to extremely low-frequency electromagnetic fields. [J]. Cardiovascular Research 2009, 3(3).
[5] ZHANG Xin, WEI Meng, ZHU Wei. Combined transplantation of endothelial progenitor cells and mesenchymal stem cells into a rat model of isoproterenol-induced myocardial injury [J]. Arch Cardio-vasc Dis 2008, 101(05).
[6] KAMIHATA H, MATSUBARA H, NISHIUE T. Improvement of collateral perfusion and regional function by implantation of peripheral blood mononuclear cells into ischemic hibernating myocardium [J]. Arteriosclerosis, Thrombosis, and Vascular Biology 2002, 22(11).
[7] PRICE M J, CHOU C C, FRANTZEN M. Intravenous mesenchymal stem cell therapy early after reperfused acute myocardial infarction improves left ventricular function and alters electrophysiolo-gic properties [J]. International Journal of Cardiology 2006, 111(02).
[8] Martin-Rendon, E, Brunskill, SJ, Hyde, CJ, Stanworth, SJ, Mathur, A, Watt, SM. Autologous bone marrow stem cells to treat acute myocardial infarction: a systematic review. [J]. European Heart Journal 2008, 15(15).
[9] Drexler H, Meyer GP, Wollert KC. [J]. Nature clinical practice. Cardiovascular medicine 2006.
[10] Yousef M, Schannwell CM, Kostering M. The BALANCE Study: clinical benefit and long-term outcome after intracoronary autologous bone marrow cell transplantation in patients with acute myocardial infarction. [J]. Journal of the American College of Cardiology 2009, 24(24).
[11] Urbanek K, Torella D, Sheikh F, De Angelis A, Nurzynska D, Silvestri F, Beltrami CA, Bussani R, Beltrami AP, Quaini F. Myocardial regeneration by activation of multipotent cardiac stem cells in ischemic heart failure [J]. Proceedings of the National Academy of Sciences of the United States of America 2005, 24(24).
[12] DAWN B, STEIN A B, URBANEK K. Cardiac stem cells delivered intravascularly traverse the vessel barrier, regenerate infracted myocardium, and improve cardiac function [J]. Proceedings of the National Academy of Sciences of the United States of America 2005, 102(10).
[13] Menasche P, Hagege AA, Scorsin M, Pouzet B, Desnos M, Duboc D, Schwartz K, Vilquin JT, Marolleau JP. Myoblast transplantation for heart failure. [J]. The Lancet 2001, 9252(9252).
[14] Johnston PV, Sasano T, Mills K, Evers R, Lee ST, Smith RR, Lardo AC, Lai S, Steenbergen C, Gerstenblith G, Lange R, Marban E. Engraftment, differentiation, and functional benefits of autologous cardiosphere-derived cells in porcine ischemic cardiomyopathy. [J]. Circulation 2009, 12(12).
[15] Chimenti I, Smith RR, Li TS, Gerstenblith G, Messina E, Giacomello A, Marban E. Relative roles of direct regeneration versus paracrine effects of human cardiosphere-derived cells transplanted into infarcted mice. [J]. Circulation research: a journal of the American Heart Association 2010, 5(5).
[16] DAVIS D R, ZHANG Yiqiang, SMITH R R. Validation of the cardiosphere method to culture cardiac progenitor cells frommyocardial tissue [J]. PLoS One 2009, 4(09).
[17] Tomescot A, Leschik J, Bellamy V, Dubois G, Messas E, Bruneval P, Desnos M, Hagege AA, Amit M, Itskovitz J, Menasche P, Puceat M. [J]. Stem Cells 2007.
[18] Kehat I, Khimovich L, Caspi O, Gepstein A, Shofti R, Arbel G, Huber I, Satin J, Itskovitz Eldor J, Gepstein L. Electromechanical integration of cardiomyocytes derived from human embryonic stem cells. [J]. Nature biotechnology 2004, 10(10).
[19] Rufaihah AJ, Haider HK, Heng BC, Ye L, Tan RS, Toh WS, Tian XF, Sim EK, Cao T. Therapeutic angiogenesis by transplantation of human embryonic stem cell-derived CD133+ endothelial progenitor cells for cardiac repair. [J]. Regenerative medicine 2010, 2(2).
[20] Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors [J]. Cell 2006, 4(4).
[21] ZHANG Jianhua, WILSON G F, SOERENS A G. Functional cardiomyocytes derived from human induced pluripotent stem cells [J]. Circulation Research 2009, 104(04).
[22] Christopher J. Lengner. iPS cell technology in regenerative medicine [J]. Annals of the New York Academy of Sciences 2010.
[23] Pasha Z, Wang Y, Sheikh R, Zhang D, Zhao T, Ashraf M. Preconditioning enhances cell survival and differentiation of stem cells during transplantation in infarcted myocardium. [J]. Cardiovascular Research 2008, 1(1).
[24] Hu X, Yu SP, Fraser JL, Lu Z, Ogle ME, Wang JA, Wei L. Transplantation of hypoxia-preconditioned mesenchymal stem cells improves infarcted heart function via enhanced survival of implanted cells and angiogenesis. [J]. The Journal of Thoracic and Cardiovascular Surgery 2008, 4(4).
[25] Haider HKh, Jiang S, Idris NM, Ashraf M. [J]. Circulation research: a journal of the American Heart Association 2008.

干细胞在心肌再生中的研究进展

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