结直肠癌患者血清淀粉样蛋白、D二聚体和CA724水平对肿瘤转移的预测

doi:10.3969/j.issn.1674-490X.2014.01.004

医学研究与教育 ›› 2014, Vol. 31 ›› Issue (1): 17-20,45.DOI: 10.3969/j.issn.1674-490X.2014.01.004

结直肠癌患者血清淀粉样蛋白、D二聚体和CA724水平对肿瘤转移的预测

胡玲¹,苏雷¹,商琰红¹,王志宇¹,李小芳¹,焦进¹,陈春燕²

1.河北大学附属医院肿瘤内科,河北保定,071000
2.安国市医院,河北安国,071200

收稿日期:2016-09-29 修回日期:2016-09-29 出版日期:2014-02-25 发布日期:2014-02-25

The changes of serum amyloid A (SAA), plasma D-dimer and tumer marker CA724 for predicting tumor metastasis of patients with colorectal cancer

HU Ling¹,SU Lei¹,SHANG Yanhong¹,WANG Zhiyu¹,LI Xiaofang¹,JIAO Jin¹,CHEN Chunyan²

Received:2016-09-29 Revised:2016-09-29 Online:2014-02-25 Published:2014-02-25

摘要/Abstract

摘要： 目的：…研究结直肠癌患者血液中血清淀粉样蛋白(SAA)、D二聚体和CA724指标的变化对结直肠癌患者肿瘤转移的预测、评估。方法…选择结直肠癌患者58例及良性疾病患者55例，于术前采血并检测SAA、血浆D二聚体和CA724的水平，随后进行统计学分析。另外，结直肠癌患者组内按照术后病理分期（AJCC/UICC）分为无区域淋巴结及无远处转移组、有区域淋巴结及无远处转移组、远处转移组，对3组间SAA、D二聚体、CA724进行比较。结果…结直肠癌患者的SAA、D二聚体、CA724水平较对照组显著升高（P<0.05）。SAA在结直肠癌患者无区域淋巴结及无远处转移组、有区域淋巴结及无远处转移组、远处转移组之间差异有统计学意义；CA724在无区域淋巴结及无远处转移组、有区域淋巴结及无远处转移组、远处转移组之间差异无统计学意义。在结直肠癌患者的各亚组中，远处转移组的SAA、D二聚体水平明显高于有区域淋巴结及无远处转移组、无区域淋巴结及无远处转移组（P<0.05）。结论…检测血液SAA、CA724及D二聚体水平对筛选结直肠癌患者区域淋巴结转移及远处转移可能有一定的指导意义。

关键词: 结直肠癌, 血清淀粉样蛋白, D二聚体, CA724

Abstract: Objective To explore the changes of serum amyloid A (SAA), plasma D-dimer and tumer marker CA724 for predicting tumor metastasis of patients with colorectal cancer. Methods Preoperative SAA, D-dimer and CA724 were measured in 58 patients with colorectal and 55 patients with benign disease, and they were analyzed with statistics method. In addition, according to pathological TNM (AJCC/UICC TNM), the patients with colorectal were divided into no metastasis group, regional lymph node metastasis group and distant metastasis group for comparing SAA, D-dimer and CA724 between groups. Results SAA, D-dimer and CA724 levels were signiifcantly higher in patients with colorectal carcinoma than those with benign diseases (P<0.05). SAA test showed that there was statistical significance between no metastasis group, regional lymph node metastasis group and distant metastasis group, and there was no statistical signiifcance by CA724. SAA and D-dimer levels in distant metastasis group were obviously higher than that of no metastasis group and regional lymph node metastasis group (P<0.05). Conclusion There is guiding signiifcance for conifrming regional lymph node metastasis and distant metastasis in patients with colorectal to detect SAA CA724 and D-dimer levels.

Key words: colon carcinoma and rectal carcinoma, serum amyloid A, CA724 antigen, D-dimer

中图分类号:

胡玲,苏雷,商琰红,王志宇,李小芳,焦进,陈春燕. 结直肠癌患者血清淀粉样蛋白、D二聚体和CA724水平对肿瘤转移的预测[J]. 医学研究与教育, 2014, 31(1): 17-20,45.

HU Ling,SU Lei,SHANG Yanhong,WANG Zhiyu,LI Xiaofang,JIAO Jin,CHEN Chunyan. The changes of serum amyloid A (SAA), plasma D-dimer and tumer marker CA724 for predicting tumor metastasis of patients with colorectal cancer[J]. Medical Reserch and Education, 2014, 31(1): 17-20,45.

参考文献

[1] 汪晓东, 高命, 吕东昊, 张程珑, 刘磊, 李立, WANG Xiao-dong, GAO Ming, LV Dong-hao, ZHANG Cheng-long, LIU Lei, LI Li. 炎性介质CRP和 SAA与肿瘤标记物CEA、CA19-9和CA72-4术前联合评估结直肠癌 [J]. 临床肿瘤学杂志 2009.doi:10.3969/j.issn.1009-0460.2009.04.012
[2] 张丽中, 赵智, 吴滨. 恶性肿瘤患者血浆纤维蛋白原和D二聚体含量的测定及其临床意义 [J]. 肿瘤研究与临床 2006.doi:10.3760/cma.j.issn.1006-9801.2006.11.016
[3] 胡玲, 杨华, 苏雷, 张磊, 刘娜, 武变瑛. 180例恶性肿瘤病人血液高凝状态的临床研究 [J]. 医学研究与教育 2010.doi:10.3969/j.issn.1674-490X.2010.05.009
[4] 钟善传, 刘涤瑕, 涂晖, 王丽, 董凤珍, 陈金超, ZHONG Shan-chuan, LIU Di-xia, TU Hui, WANG Li, DONG Feng-zhen, CHEN Jin-chao. IL-6、CEA、CA19-9和CA72-4对胃癌的诊断价值 [J]. 标记免疫分析与临床 2011.doi:10.3969/j.issn.1006-1703.2011.04.008
[5] 汪晓东, 李亚伦, 邱萌, 罗德云, 李立, WANG Xiao-dong, LI Ya-lun, QIU Meng, LUO De-yun, LI Li. 多学科协作诊治模式下新辅助化疗对直肠癌手术的影响 [J]. 中国普外基础与临床杂志 2008.
[6] KOHNO N, AKIYAMA M, KYOIZUMI S. New serum indicator of activity of interstitial pneumonitis:Sialylated carbohydrate antigen KL-6 [J]. CHEST 1989, 96(01).
[7] Chen Y, Hyrien O, Williams J, Okunieff P, Smudzin T, Rubin P. Interleukin (IL)-1A and IL-6: Applications to the predictive diagnostic testing of radiation pneumonitis. [J]. International Journal of Radiation Oncology, Biology, Physics 2005, 1(1).
[8] Tseng CS, Lo HW, Chen PH, Chuang WL, Juan CC, Ker CG. Clinical significance of plasma D-dimer levels and serum VEGF levels in patients with hepatocellular carcinoma. [J]. Hepato-gastroenterology 2004, 59(59).
[9] Gutfeld O, Prus D, Ackerman Z, Dishon S, Linke RP, Levin M, Urieli-Shoval S. Expression of serum amyloid A, in normal, dysplastic, and neoplastic human colonic mucosa: Implication for a role in colonic tumorigenesis [J]. The Journal of Histochemistry and Cytochemistry 2006, 1(1).
[10] MAZHAR D, NGAN S. C-reactive protein and colorecta1 cancer [J]. QUARTERLY JOURNAL OF MEDICINE 2006, 99(08).
[11] Glojnaric I, Casl MT, Simic D, Lukac J. Serum amyloid A protein (SAA) in colorectal carcinoma. [J]. Clinical chemistry and laboratory medicine: CCLM 2001, 2(2).
[12] MASATOSHI O, YOSHITAKE A, TAKASHI O. High preoperative plasma D-dimer level is associtated with advanced tumor and short sur. vival after curative resection in patients with colorectal cancer [J]. Japanese Journal of Clinical Oncology 2001, 31(08).
[13] YCHOU M, DUFF0UR J, KRAMAR A. Clinical significance and prognostic value of CA724 compared with CEA and CA199 in patients with gastric cancer [J]. DISEASE MARKERS 2000, 16.

结直肠癌患者血清淀粉样蛋白、D二聚体和CA724水平对肿瘤转移的预测

The changes of serum amyloid A (SAA), plasma D-dimer and tumer marker CA724 for predicting tumor metastasis of patients with colorectal cancer

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