关键词: 乌鸡白凤丸, 阿立哌唑, 利培酮, 高催乳素血症

Abstract: Objective To explore the efficacy and safety of Wujibaifeng pills and aripiprazole in the treatment of female hyperprolactinemia caused by risperidone. Methods 67 female schizophrenia patients with hyperprolactinemia caused by risperidone and aripiprazole were randomly assigned into Wujibaifeng pills group and aripiprazole group treated for 4 weeks. Results In Wujibaifeng pills group 28 cases were completed the treatment, in aripiprazole group 30 cases completed. In Wujibaifeng pills group, the serum prolactin was significantly lower than before treatment (t=7.624, P=0.000), serum prolactin in aripiprazole group was significantly lower than that before treatment (t=8.278, P=0.000). The serum prolactin levels in the two groups had no significant difference (t=1.965, P=0.054) .Conclusion Wujibaifeng pills and aripiprazole can reduce risperidone induced hyperprolactinemia level with good safety.

Key words: Wujibaifeng pills, Aripiprazole, Rispiprazole, hyperprolactinemia