细胞凋亡与血管再生促进纤维化发展的机制研究

doi:10.3969/j.issn.1674-490X.2015.04.009

医学研究与教育 ›› 2015, Vol. 32 ›› Issue (4): 33-37.DOI: 10.3969/j.issn.1674-490X.2015.04.009

细胞凋亡与血管再生促进纤维化发展的机制研究

屈朋欢¹，史建红²

1. 河北大学公共卫生学院，河北保定 071000；2. 河北大学附属医院中心实验室，河北保定 071000

出版日期:2015-08-25 发布日期:2015-08-25
通讯作者: 史建红（1980—），女，河北保定人，副教授，博士，主要从事分子生物学研究。 E-mail: shijianhong1980@126. com
作者简介:屈朋欢（1991—），女，河北保定人。E-mail: qupenghuan@sina. com
基金资助:
国家自然科学基金青年基金（31301143）; 河北省自然科学基金青年基金（C2013201271）

Study on the mechanism of apoptosis and angiogenesis in promoting the development of fibrosis

QU Penghuan¹, SHI Jianhong²

1. College of Public Health, Hebei University, Baoding 071000,China; 2. Affiliated Hospital Central Laboratory of Hebei University, Baoding 071000,China

Online:2015-08-25 Published:2015-08-25

摘要/Abstract

摘要： 纤维化经常发生在肝脏、肺、心脏、肾脏和皮肤等重要脏器。细胞凋亡已经被认定为纤维化潜在的启动和促进者。凋亡细胞的出现对成纤维细胞表型和胶原蛋白代谢有重要影响。同时，在纤维化的模型中发现血管生成和退化普遍出现在纤维化之前，暗示着血管凋亡对于纤维化是重要的。而且血管生成抑制剂在实验研究中已显示出较好的抗肝纤维化疗效。新近的证据表明血管生成或退化有助于纤维化，而最初的血管衍生物或凋亡细胞的出现可能是纤维化的调控者。

关键词: 细胞凋亡, 血管新生, 纤维化

Abstract: Fibrosis is usually seen in the liver, lung, heart, kidney and skin. Apoptosis has been identified as a potential initiator and propagator of fibrosis. The occurrence of apoptosis has an important effect on fibroblast phenotype and collagen metabolism. Simultaneously, fibrosis in these models is generally preceded by robust angiogenesis and vascular regression, suggesting that the vascular apoptotic burden may be important to fibrotic outcomes. Angiogenesis inhibitors in the experimental research has shown good curative effect against liver fibrosis. This review considers the emerging evidence that angiogenesis or vascular regression contributes to fibrosis and identifies initial vascular outgrowth or vascular apoptotic cell presence as possible regulators of fibrosis.

Key words: apoptosis, angiogenesis, fibrosis

屈朋欢，史建红. 细胞凋亡与血管再生促进纤维化发展的机制研究[J]. 医学研究与教育, 2015, 32(4): 33-37.

QU Penghuan, SHI Jianhong. Study on the mechanism of apoptosis and angiogenesis in promoting the development of fibrosis[J]. Medical Reserch and Education, 2015, 32(4): 33-37.

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细胞凋亡与血管再生促进纤维化发展的机制研究

Study on the mechanism of apoptosis and angiogenesis in promoting the development of fibrosis

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