腹腔镜结直肠癌NOSES疗效分析以及对氧化应激、炎性反应的影响

doi:10.3969/j.issn.1674-490X.2020.05.005

摘要/Abstract

摘要： 目的探究采用腹腔镜结直肠癌标本经自然腔道取出术(natural orifice specimen extraction surgery, NOSES)治疗结直肠癌的临床疗效以及对患者氧化应激、炎症反应的影响。方法选择2018年3月至2019年11月于南阳市第二人民医院胃肠外科接受手术治疗的134例结直肠癌患者,并根据术式不同分为2组。其中观察组67例给予腹腔镜NOSES,对照组67例采用腹腔镜结直肠癌根治术,治疗后再对比2组手术相关指标、氧化应激以及炎症反应情况。结果观察组首次排气时间、术后住院时间分别为(26.32±3.13)h、(6.62±0.77)d,均显著低于对照组,差异有统计学意义(P<0.05);术后24 h 2组MDA均显著升高,SOD水平均显著降低,且观察组MDA升高幅度与SOD降低幅度均显著低于对照组,差异有统计学意义(P<0.05);术后24 h 2组TNF-α、CRP、IL-6水平均显著升高,IL-10水平显著降低,且观察组TNF-α、CRP、IL-6水平升高幅度与IL-10水平降低幅度显著低于对照组,差异有统计学意义(P<0.05)。结论结直肠癌患者采用腹腔镜NOSES能够有效改善氧化应激与炎症反应,术后康复效果显著。

关键词: 结直肠癌, 腹腔镜, 自然腔道取出术, 氧化应激, 炎症反应

Abstract: Objective To explore the clinical effect of laparoscopic colorectal cancer natural orifice specimen extraction surgery(NOSES)in the treatment of colorectal cancer, as well as the effect on oxidative stress and inflammatory response of patients. Methods 134 patients with colorectal cancer who received surgical treatment in our hospital from March 2018 to November 2019 were divided into two groups according to different surgical procedures. Among them, 67 patients in the observation group received laparoscopic NOSES operation, 67 patients in the control group received laparoscopic colorectal cancer radical surgery. After treatment, the operation related indicators, oxidative stress and inflammatory response were compared between the two groups. Results The first exhaust time and postoperative hospitalization time of the observation group were(26.32±3.13)h and(6.62±0.77)d, respectively, which were significantly lower than those of the control group, with statistical difference(P<0.05). The MDA and SOD levels of the two groups were significantly higher and lower 24 hours after operation, and the MDA and SOD levels of the observation group were significantly lower than those of the control group, with statistical difference(P<0.05). 24 hours after operation, the two groups The levels of TNF-α, CRP and IL-6 in the observation group were significantly higher than those in the control group(P<0.05). Conclusion Laparoscopic NOSES can effectively improve oxidative stress and inflammation in patients with colorectal cancer, and the postoperative rehabilitation effect is significant, which is worthy of clinical application.

Key words: colorectal cancer, laparoscopy, natural orifice specimen extraction surgery, oxidative stress, inflammatory response

中图分类号:

柴素伟. 腹腔镜结直肠癌NOSES疗效分析以及对氧化应激、炎性反应的影响[J]. 医学研究与教育, 2020, 37(5): 31-35.

[1]	张静波, 史坚, 杨静云, 冉继鹏, 刘子腾, 张莎莎. 抗核抗体与主动脉壁间血肿发生的相关性分析[J]. 医学研究与教育, 2022, 39(5): 19-24.
[2]	翟博,朱乾坤,李小东,胡凤丽,金鑫. 学习风格特征对腹腔镜扶镜技能训练的影响[J]. 医学研究与教育, 2022, 39(3): 74-80.
[3]	朱健平,李运曼. Nrf2在缺血性脑损伤中的关键性作用[J]. 医学研究与教育, 2022, 39(2): 1-9.
[4]	庄建港. 替罗非班对急性脑梗死机械取栓患者氧化应激水平及神经功能的影响[J]. 医学研究与教育, 2021, 38(5): 20-25.
[5]	翟博, 李小东, 朱乾坤, 胡凤丽, 金鑫. 互联网+3D打印模型在腹腔镜外科基本技能培训中的应用[J]. 医学研究与教育, 2021, 38(2): 66-70.
[6]	周程艳,李倩,梁宇璇,国洪宾,赵盈秋. 两种动脉粥样硬化模型制备方法的比较[J]. 医学研究与教育, 2021, 38(1): 1-11.
[7]	王云,殷小平. 影像基因组学在结直肠癌肝转移诊疗中的应用进展[J]. 医学研究与教育, 2020, 37(5): 14-20.
[8]	朱波,刘经纬,豆建,李日恒. 表观遗传药物在结直肠癌治疗中的研究进展[J]. 医学研究与教育, 2020, 37(4): 13-19.
[9]	潘秀敏,张金立,闫红丽,李梦琳,郭敬如. 高选择性肾动脉分支阻断与全阻断下腹腔镜保留肾单位手术疗效及肾功能对比[J]. 医学研究与教育, 2020, 37(1): 30-35.
[10]	周雪,李贲,李志红,郭淑芹,张文娟. 利拉鲁肽对缺氧/复氧条件下乳鼠心肌细胞PI3K途径信号通路的作用[J]. 医学研究与教育, 2018, 35(6): 24-29.
[11]	赵鹏辉,刘宣辰,吴银玲,田园,葛少钦. 五味子乙素抗氧化作用研究进展[J]. 医学研究与教育, 2018, 35(4): 1-5.
[12]	张欢,靳小石,王强,矫政洧,程树杰. 结直肠癌与抑癌基因SLC5A8甲基化的相关性[J]. 医学研究与教育, 2017, 34(1): 1-6.
[13]	卢志茹,李力. 剖宫产术后全身炎症反应综合征4例临床分析[J]. 医学研究与教育, 2016, 33(3): 73-76.
[14]	宋艳敏，李日恒，张涛，贾佳，马芳，赵立华. 结直肠癌中 PAQR3 甲基化水平及 mRNA 表达的研究[J]. 医学研究与教育, 2015, 32(1): 55-60.
[15]	郝捷,于红莲. 腹腔镜下射频消融治疗孤立肾肾细胞癌的护理[J]. 医学研究与教育, 2014, 31(4): 51-56.

腹腔镜结直肠癌NOSES疗效分析以及对氧化应激、炎性反应的影响

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价