NF-κB信号通路与胃癌的研究进展

doi:10.3969/j.issn.1674-490X.2017.01.006

摘要/Abstract

摘要： 胃癌是全球常见的一种癌症,具有较高的发病率和病死率,目前关于胃癌发病机制的研究很多,但其确切机制迄今仍不清楚。核转录因子κB( nuclear factor kappa B,NF-κB)广泛存在于细胞中,并与肿瘤细胞分化、增殖、凋亡、免疫应答等应激反应息息相关,而胃癌的发生发展、浸润转移、治疗预后都涉及NF-κB信号通路的紊乱。本文就近年来NF-κB信号通路在胃癌发病机制中的研究进展作一综述。

关键词: 核转录因子κB, 胃癌, 信号通路

Abstract: Gastric cancer is a common cancer,with high morbidity and mortality.Despite there are a lot of research on the pathogenesis of gastric cancer,but the exact mechanism is still unclear.Nuclear factor kappa B(NF-κB)exists widely in cells which are significantly related to differentiation,proliferation,apoptosis,immune response and stress response.In addition to the NF-κB signaling pathway disorders in gastric cancer in the origin and development,invasion and metastasis,therapy and prevention are involved.We summarize recent progress in understanding the role of the NF-κB pathway in gastric cancer.

Key words: NF-κB, gastric cancer, signaling pathway

中图分类号:

杨舒,张雷. NF-κB信号通路与胃癌的研究进展[J]. 医学研究与教育, 2017, 34(1): 33-38.

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