miRNA-425-5P在胃癌中的表达及临床价值

doi:10.3969/j.issn.1674-490X.2021.04.003

医学研究与教育 ›› 2021, Vol. 38 ›› Issue (4): 18-22.DOI: 10.3969/j.issn.1674-490X.2021.04.003

miRNA-425-5P在胃癌中的表达及临床价值

张牙^1,2,程树杰³,许佳义²,魏亚宁⁴,张卓奇²

1.河北大学临床医学院, 河北保定 071000;
2.河北大学附属医院胃肠外科, 河北保定 071000;
3.河北大学附属医院, 河北保定 071000;
4.河北大学附属医院肿瘤内科, 河北保定 071000

收稿日期:2021-07-24 出版日期:2021-08-25 发布日期:2021-08-25
通讯作者: 张卓奇(1975—),男,河北保定人,副主任医师,博士,硕士生导师,主要从事胃肠外科工作。E-mail: zzq13831218585@163.com
作者简介:张牙(1993—),男,安徽宿州人,在读硕士。通信作者:张卓奇(1975—),男,河北保定人,副主任医师,博士,硕士生导师,主要从事胃肠外科工作。 E-mail: zzq13831218585@163.com
基金资助:
河北省政府资助临床医学优秀人才培养项目(361007)

Received:2021-07-24 Online:2021-08-25 Published:2021-08-25

摘要/Abstract

摘要： 目的探讨miRNA-425-5P在胃癌中的表达及其与临床病理特征的关系。方法利用实时荧光定量PCR(qRT-PCR)法检测90例胃癌组织及胃癌细胞(MGC-803、SGC-7901)中miRNA-425-5P的表达量,分析miRNA-425-5P与临床病理特征的关系。结果 miRNA-425-5P在胃癌组织及胃癌细胞中高表达(P<0.05),且miRNA-425-5P的表达与胃癌的浸润深度(χ²=6.106,P=0.014)、TNM分期(χ²=4.472,P=0.035)有关,但与患者年龄(χ²=0.266,P=0.606)、性别(χ²=1.593,P=0.207)、淋巴转移(χ²=1.829,P=0.176)和有无神经血管侵犯(χ²=1.029,P=0.310)无关。结论 miRNA-425-5P在胃癌组织和细胞中高表达,是胃癌预后不良的独立危险因素,有望作为胃癌诊断、治疗和评价预后的标志物。

关键词: miRNA-425-5P, 胃癌, 表达, 预后

Abstract: Objective To observe the relationship between the expression of miRNA-425-5P and clinicopathological features of gastric cancer(GC)patients. Methods The expression of miRNA-425-5P in 90 cases of GC tissues and cells(MGC-803, SGC-7901)were detected with qRT-PCR assay. The relationship between miRNA-425-5P expression and clinicopathological features of gastric cancer were analyzed. Results The expression of miRNA-425-5P in GC tissues and cells were significantly increased(P<0.05), and it correlated with depth of invasion(χ²=6.106, P=0.014)and TNM stages(χ²=4.472, P=0.035), rather than the age(χ²=0.266, P=0.606), sex(χ²=1.593, P=0.207), lymphatic metastasis(χ²=1.829, P=0.176)and nerve/vessel invaded(χ²=1.029, P=0.310)of GC patients. Conclusion The expression of miRNA-425-5P is an independent prognostic risk factors of gastric cancer, which can be expected to serve as a marker for the diagnosis, treatment, and evaluation of the prognosis of gastric cancer in clinical practice.

Key words: miRNA-425-5P, gastric cancer, expression, prognosis

中图分类号:

张牙,程树杰,许佳义,魏亚宁,张卓奇. miRNA-425-5P在胃癌中的表达及临床价值[J]. 医学研究与教育, 2021, 38(4): 18-22.

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miRNA-425-5P在胃癌中的表达及临床价值

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