冠心病与生物钟关联靶基因的生物信息学挖掘

doi:10.3969/j.issn.1674-490X.2020.05.001

摘要/Abstract

摘要： 目的分析生物节律紊乱与冠心病发生关联的潜在分子机制。方法从GEO数据库中获取GSE71226芯片数据,用R软件筛选冠心病差异表达基因;经文本挖掘和蛋白互作分析获得生物钟相关基因,进行功能注释、染色体定位和互作分析。结果获得488个冠心病差异表达基因(coronary heart disease differentially expressed genes, CHD-DEGs)和64个生物钟相关基因(biological clock related genes, BRGs),在染色体上分布密集,且多与转录调控、炎症和免疫系统疾病相关。其中28个CHD-DEGs与22个BRGs发生了显著互作,有10个重要关联靶基因。结论生物节律紊乱与冠心病的发生之间存在着密切的关联。

关键词: 生物钟, 冠心病, 生物信息学, 染色体定位, 富集分析

Abstract: Objective To analyze the potential molecular mechanism of coronary heart disease induced by biorhythm disorder. Methods GSE71226 dataset was downloaded from Gene Expression Omnibus(GEO). R software was used to identify coronary heart disease differentially expressed genes(CHD-DEGs), through text mining and protein interaction analysis, biological clock related genes(BRGs)were obtained, and functional annotation, chromosome location and interaction analysis were carried out. Results 488 CHD-DEGs and 64 BRGs were obtained, which densely distributed on chromosomes, mostly related to transcription regulation, inflammation and immune system diseases. Among them, 28 CHD-DEGs interacted significantly with 22 BRGs, and there were 10 important associated target genes. Conclusion Biological rhythm disorder is closely related to the occurrence of coronary heart disease.

Key words: biological clock, coronary heart disease, bioinformatics, chromosome location, enrichment analysis

中图分类号:

R392

王文栋,苏翰博,樊茜茜,李喜龙,常晓彤. 冠心病与生物钟关联靶基因的生物信息学挖掘[J]. 医学研究与教育, 2020, 37(5): 1-13.

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