老年患者术后谵妄的病理生理机制研究进展

doi:10.3969/j.issn.1674-490X.2022.04.002

摘要/Abstract

摘要： 术后谵妄以注意力下降、意识和认知紊乱、知觉障碍为特点,好发于老年患者,与延长住院时间、增加经济负担、降低生活质量、增加术后病死率等密切相关。目前,术后谵妄的病理生理和发病机制尚未完全明确,也缺乏有效的生物学指标及临床指标,所以在一定程度上影响了术后谵妄的早期诊断和预防。就近几年术后谵妄的发病机制学说进行综述,以期从生理机制方面更明确地了解术后谵妄,为临床上术后谵妄的预防和治疗提供更有效的方法。

关键词: 老年, 术后谵妄, 病理生理机制

Abstract: Postoperative delirium(POD)is characterized by decreased attention,consciousness and cognitive disorders and perceptual disorders.It tends to occur in elderly patients,and is closely related to prolonged hospital stay,increased economic burden,reduced quality of life and increased postoperative mortality.At present,the pathophysiology and pathogenesis of POD have not been fully defined,and there are no effective biological and clinical indicators,which affects the early diagnosis and prevention of POD to a certain extent.This paper reviews the pathogenesis of POD in recent years in order to have a clearer understanding of POD from the physiological mechanism and provide more effective methods for the prevention and treatment of POD in clinic.

Key words: older, postoperative delirium, pathophysiological mechanism

中图分类号:

R749

高旗,孙天培,武广义. 老年患者术后谵妄的病理生理机制研究进展[J]. 医学研究与教育, 2022, 39(4): 8-13.

GAO Qi,SUN Tianpei,WU Guangyi. Advances on pathophysiological mechanism of postoperative delirium in elderly patients[J]. Journal of Hebei Medical College for Continuing Education, 2022, 39(4): 8-13.

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