Mesenchymal stem cells for cardiac repair: opportunities and challenges

doi:10.3969/j.issn.1674-490X.2022.05.005

Abstract

Abstract: Mesenchymal stem cells(MSCs)are a kind of adult stem cells residing in a variety of tissues, such as bone marrow, adipose tissue and umbilical cord. With the developments of standard procedures and protocols for isolation, culturing and characterization of these cells, MSCs have emerged as an ideal seed cell for myocardial repair. When transplanted into a injured heart, MSCs have paracrine effects that nurture the injured area, prevent adverse cardiac remodeling, and mediate angiogenesis capabilities. MSCs have short survival time and risk of tumor formation, so they have not been widely used in clinic. In order to improve the therapeutic potential of MSCs and ensure its therapeutic safety, many methods such as gene modification, drug induction and bioengineering have moved from basic research to clinical practices, making MSCs become a high-quality resource cells for myocardial repair, bring new opportunity to myocardial infarction and end-stage heart failure.

Key words: myocardial infarction, heart failure, myocardial repair, paracrine, mesenchymal stem cells

CLC Number:

ZHANG Hongqiang, ZHANG Bing, LI Jianqi, JU Hailong. Mesenchymal stem cells for cardiac repair: opportunities and challenges[J]. Journal of Hebei Medical College for Continuing Education, 2022, 39(5): 25-30.

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