doi:10.3969/j.issn.1674-490X.2023.03.005

Abstract

Abstract: The clinical characteristics of acute lung injury(ALI)are decreased oxygenation index, refractory hypoxemia and then further development of acute respiratory distress syndrome in critically ill patients with high morbidity and mortality. The etiology of ALI is varied, such as direct lung injury and indirect lung injury. Each etiology leads to a different treatment for ALI, especially the use of glucocorticoids. However, the use strategy of ALI is different, and there are serious complications after long-term use, so its use should be cautious. Therefore, understanding the application progress and potential mechanism of glucocorticoids is helpful to better use glucocorticoids and reduce their side effects. This article provides an overview of summary about using glucocorticoids in ALI of different etiology, including the experimental application of animal models and the methods commonly used in clinical practice, and the mechanism behind it, providing reference for efficient treatment.

Key words: acute lung injury, glucocorticoid, pathogenesis

CLC Number:

References

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