Abstract: Objective To analyze the MLNM detection rate, sensitivity and accuracy with spiral CT scanning, tumor markers and both of them and assess the value of the combination of tumor markers and CT scanning in clinic diagnosis of MLNM in lung cancer. Methods 110 cases (male 64, female 46, aged 41 to 47) hospitalized in Baoding No.3 hospital from September 2010 to August 2011 were selected. Radiations were taken with a Siemens spiral CT machine, under 130 kV, 110 mAs. C-12 protein chip system for multi-tumor marker detection was used. Results Positive diagnosis of MLNM with CT was 33, with sensitivity of 67.35%and specificity of 70.49%. As to tumor markers, the sensitivity was 77.55%and the specificity was 59.02%. When combined, the sensitivity was significantly higher (P<0.01) up to 91.84%, and the specificity was 65.57%, the accuracy was 77.27%. Conclusion The combination of Multi-Tumor Marker Protein Chip technique and spiral CT, comparing with either single technique, can significantly increase the diagnosis sensitivity and accuracy of MLNM, furthermore increase the diagnosis accuracy of TNM stages in lung cancer.

Key words: tumor markers, X-ray computed tomography, combined testing, mediastinum lymph node