Abstract: Objective To investigate the treating mechanism of Fuzhenghuoxueqingrefang on acute radiation enteritis(ARE)in rats. Methods Thirty two Wistar male rats were randomly divided into 4 groups(8 rats each group), which were composed of blank control, model, dexamethasone, and Fuzhenghuoxueqingrefang groups. The physiological saline, dexamethasone and Fuzhenghuoxueqingrefang were administrated separately at the ifrst day after abdominal irradiation by daily rectal clysma for 5 days. All the rats were anesthetized and the serum activity of peroxidase (CAT) and contents of malonic aldehyde(MDA) were detected at the seventh day after abdominal irradiation separately. Results The activity of serum CAT in the blank control, dexamethasone and Fuzhenghuoxueqingrefang groups were obviously higher than that of the model group(F=23.79, P<0.01). The content of serum MDA in the blank control, dexamethasone and Fuzhenghuoxueqingrefang groups were signiifcantly lower than that of the model groups(F=36.41, P<0.01). Conclusion Fuzhenghuoxueqingrefang could treat ARE in rats by down-regulating the lipid peroxidation in the damaged tissue.

Key words: Fuzhenghuoxueqingrefang, acute radiation enteritis, CAT, MDA