Abstract: Objective To investigate the positive rates of islet cell autoantibody (ICA), glutamic acid decarboxylase antibody (GADA) and insulin autoantibody (IAA) in plasma of patients with type 1 diabetes mellitus (T1DM) and Helicobacter pylori (HP) infection versus patients with T1DM but not HP, and then to detect the changes in these ntibodies after HP eradication. Methods HP was eradicated using triple therapy with omeprazole (20 mg, bid), clarithromycin (0.5 g, bid) and amoxicillin (1.0 g, bid). Before and after HP eradication, enzyme-linked immunosorbent assay (ELISA) was used to determine the levels of diabetes-related antibodies. Results Compared with patients with T1DM, higher positive rate of ICA was observed in patients with both T1DM and HP infection. Furthermore, the result was statistically significant. In contrast, there were no differences in GADA and IAA between two groups of patients. After HP eradication, the positive rates of ICA, GADA and IAA were not altered significantly. Conclusion HP infection elevates the positive rate of ICA in patients with T1DM, but HP eradication has no significant effects on the levels of gADA and IAA.

Key words: Helicobacter pylori, diabetes, isled cell antibody