Abstract: Objective To investigate the relationship of JAK2V617F mutation and cerebrovascular events in patients with myeloproliferative neoplasms(MPN). Methods The JAK2V617F mutation of 64 patients with MPN was detected. We performed a retrospective study on the incidence of cerebrovascular events(cerebral infarction, transient ischemic attack, cerebral hemorrhage, subarachnoid hemorrhage) in 64 patients with MPN. Statistical analysis was applied on the incidence rate of cerebrovascular events between JAK2V617F mutation positive group and negative group and between groups of different diseases with JAK2V617F mutation. Results Of 64 patients with MPN, JAK2V617F mutation was detected in 47 cases (73.4%). There were a total of 38(59.4%) cerebrovascular events. The incidence rate of cerebrovascular events in JAK2V617F mutation positive and negative patients were 68.1% and 35.3% respectively, P=0.018. The incidence rate between PV and ET patients with JAK2V617F mutation were statistically non-significant. Conclusion The risk of cerebrovascular events in MPN patients with JAK2V617F mutation may be higher.

Key words: myeloproliferative neoplasms, JAK2V617F, hemorrhage, thrombosis