Application of potential of mesenchymal stem cell in the treatment of cancer

doi:10.3969/j.issn.1674-490X.2015.05.023

Abstract

Abstract: Stem cell treatments are being increasingly explored for their possible potential to treat various cancers. Mesenchymal stem cells are believed to possess anti-tumor potential and are preferred for their properties like immune privileged nature, ability to migrate to the site of tumor and capability for multilineage differentiation. This tumor tropism property of MSCs could be utilized to deliver anti-tumor biological agents to the site of tumor. In a tumor micro-environment, MSCs are believed to play both, a pro-tumorigenic and an anti-tumorigenic role. However, this is dependent on a host of factors like, types of MSCs, its source, type of cancer cell line under investigation, interactions between MSCs, host’s immune cells and cancer cells. Among several cytokines secreted by MSCs, TRAIL (Tumor necrosis factor related apoptosis inducing ligand) are reported to be pro-apoptotic for tumor cells. Umbilical cord tissue derived MSCs are believed to regulate TRAIL expression in MSC-cancer cell co-culture system resulting in induction of apoptosis in cancer cells. We present a review concerning on pro-tumorigenic and anti-tumorigenic properties of MSCs based on different studies reporting.

Key words: mesenchymal stem cells, tumor, tropism, anti-cancer

CLC Number:

JU Hailong, LIANG Lu, BIAN Jianfei, ZHANG Bing. Application of potential of mesenchymal stem cell in the treatment of cancer[J]. Medical Reserch and Education, 2015, 32(5): 93-97.

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