doi:10.3969/j.issn.1674-490X.2019.05.001

Abstract

Abstract: Objective To study the correlation between recurrent upper respiratory tract infection and LL-37,IL-10 and vitamin D.Methods 64 children with recurrent respiratory infection were randomly divided into two groups.The experimental group was treated in a routine way with vitamin D supplementation,while the control group was treated in a routine way with placebo.The follow-up period was 12 months.Plasma 25-hydeoxyvitamin D₃,IL-10 and sputum supernatant LL-37 at baseline before treatment and changes of them after 12 months were detected.Results Compared with the control group,the content of LL-37,IL-10 and 25-hydroxyvitamin D₃ in the experimental group were significantly increased(P<0.05),while the number of respiratory infections was decreased significantly(P<0.05).In the experimental group,the content of LL-37,IL-10 and 25-hydroxyvitamin D₃ were significantly increased after 12 months treatment(P<0.05),while the number of upper respiratory infections was decreased significantly(P<0.05).The LL-37 content,IL-10 content and 25-hydroxyvitamin D₃ content in the experimental group were positively correlated(P<0.05).Discussion Vitamin D supplementation helps to reduce the number of recurrent upper respiratory infections,which may be associated with increased production of LL-37 and IL-10.

Key words: recurrent respiratory infection, vitamin D₃, LL-37, IL-10

CLC Number:

References

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