The key role of Nrf2 in ischemic stroke

doi:10.3969/j.issn.1674-490X.2022.02.001

Abstract

Abstract: Ischemic stroke is one of the main causes of death and disability worldwide. Nuclear factor E2-related factor 2(Nrf2)is an important transcription factor that regulates the balance of the body's redox reaction. It participates in resisting endogenous or exogenous stress by coordinating a variety of cytoprotective genes. The Nrf2 signaling pathway not only strictly regulates the body's redox homeostasis, but also participates in the regulation of multiple processes in the body metabolism. Therefore, targeting Nrf2 has become a potential strategy for the prevention and treatment of central nervous system diseases including ischemic stroke. In this review, we first introduced the structural features of Nrf2 and Kelch-like ECH-related protein 1(Keap1), and briefly described the activation and regulation of the Nrf2 pathway. Next, we discussed the pathological and physiological mechanism, upstream regulators and downstream targets of the Nrf2 pathway. In this context, we extended the discussion to the role of Nrf2 after ischemic stroke and explored potential therapeutic directions.

Key words: ischemic stroke, Nrf2, oxidative stress, neuroinflammation, blood-brain barrier

CLC Number:

R743.3

ZHU Jianping, LI Yunman. The key role of Nrf2 in ischemic stroke[J]. Journal of Hebei Medical College for Continuing Education, 2022, 39(2): 1-9.

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