Clinical significance of molecular markers expression in invasive ductal breast cancer and ductal carcinoma in situ

doi:10.3969/j.issn.1674-490X.2015.03.007

Abstract

Abstract: Objective To explore the clinical significance of molecular markers expression in invasive ductal breast cancer and ductal carcinoma in situ. Methods SP immunohistochemical were used to detect the expression of molecular markers（BRCA1, BRCA2, C-erbB-2, P53, Bcl-2） in 100 cases of invasive ductal breast cancer, 60 cases of ductal carcinoma in situ, and 100 cases of Hyperplastic disease. The changes reasons and correlation between molecular markers and breast cancer were analyzed. Results Contrast of ductal carcinoma in situ and Hyperplastic disease, biological molecular markers of 100 cases of invasive ductal breast cancer (BRCA1, BRCA2, C-erbB-2, P53, Bcl-2) all had some changes, and the changes of BRCA1, P53 expression were correlated with breast cancer（P<0.05）. Conclusion Expression of BRCA1, P53 protein can be helpful in the prediction of the biological behavior and prognosis of invasive ductal breast cancer.

Key words: breast cancer, BRCA1, BRCA2, C-erbB-2, P53, Bcl-2, Immunohistochemistry

CLC Number:

R287

ZHANG Gang, QI Juan, LI Zhong, LIN Xiaomeng, CAI Qianqian, HAO Xin. Clinical significance of molecular markers expression in invasive ductal breast cancer and ductal carcinoma in situ[J]. Medical Reserch and Education, 2015, 32(3): 31-35.

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Clinical significance of molecular markers expression in invasive ductal breast cancer and ductal carcinoma in situ

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