Study of carotid atherosclerosis in middle-aged and young patients of cerebral infarction with sleep apnea-hypopnea

doi:10.3969/j.issn.1674-490X.2015.06.006

Abstract

Abstract: Objective To investigate the carotid atherosclerosis(CAS)in middle-aged and young patients of cerebral infarction (CI) with sleep apnea-hypopnea (SA). Methods 80 middle-aged and young patients of CI were divided into two groups, only CI group (40 cases)) and CI combined with SA group (cases 40).All patients were checked carotid artery through color doppler ultrasound and record intima-media thickness(IMT) and the state of plaques. Results The IMT of middle-aged and young patients in CI combined with SA group and in only CI group were (1.335±0.219)mm,(1.088±0.202)mm respectively, the degree of IMT in CI combined with SA group was significantly higher than that in only CI group (P<0.01).The rate of plaque occurrence in CI combined with SA group and in only CI group were 75%,25% respectively, the rate of plaque occurrence in CI combined with SA group was significantly higher than that in only CI group (P<0.01).The rate of unstable plaque occurrence in CI combined with SA group and in only CI group were 71%,30% respectively, the rate of unstable plaque occurrence in CI with SA group was significantly higher than that in only CI group (P<0.05). Conclusion There is higher degree of carotid artery atherosclerosis in the middle-aged and young patients of CI combined with SA group than that of only CI group.

Key words: cerebral infarction, sleep apnea-hypopnea, carotid atherosclerosis, middle-aged and young patients

CLC Number:

ZHAO Huixin, MENG Yanan, ZHANG Xinghong, SU Likai, ZHEN Jing, WANG Xingwei, SHI Fuping. Study of carotid atherosclerosis in middle-aged and young patients of cerebral infarction with sleep apnea-hypopnea[J]. Medical Reserch and Education, 2015, 32(6): 30-33.

References

[1] 杨秀平, 赵尧辉, 冯玉婧, 等. 阻塞性睡眠呼吸暂停低通气综合征与脑梗死的关系[J]. 中国动脉硬化杂志, 2015, 23(7): 713716. [2] 曹毅, 唐海红, 何疆春, 等. 老年人群阻塞性睡眠呼吸暂停与无症状脑梗死的相关性[J]. 国际脑血管病杂志, 2015, 23(2): 81-85. [3] HunT K J, BAKER n, ClEARy P, et al. Oxidized lDl and AGElDl in circulating immune complexes strongly predict progression of carotid artery IMT in type 1 diabetes[J]. Atherosclerosis, 2013, 231(2): 315-322. [4] 缪杰. 颈动脉粥样硬化斑块稳定性与脑梗死的相关性分析[J]. 中国中西医结合影像学杂志, 2015, 13(1): 85-86. [5] 黄铮, 龚兰生, 施仲伟, 等. 冠心病患者颈动脉粥样硬化斑块的好发部位及其超声分型[J]. 中国超声医学杂志, 1996, 12(5): 34-37. [6] MOHSEnIn V. Sleep-related breathing disorders and risk of stroke[J]. Stroke, 2001, 32(6): 1271-1278. [7] DAS A M, KHAn M. Obstructive sleep apnea and stroke[J]. Expert Cardovasc Ther, 2012, 10(4): 525-535. [8] SHAHAR E, WHITnEy C W, REDlInE S, et al. Sleep-disordered breathing and cardiovascular disease: cross-sectional results of the Sleep Heart Health Study[J]. Am J Respir Crit Care Med, 2001, 163(1): 19-25. [9] 黎娇, 况九龙. 阻塞性睡眠呼吸暂停低通气综合征氧化应激与心血管疾病相关性的研究进展[J]. 实用医学杂志, 2014, 30(12): 2002-2004. [10] 陈碧, 张文辉, 陈玉玲, 等. 阻塞性睡眠呼吸暂停低通气综合征与颈动脉粥样硬化的相关性及持续气道正压通气治疗的作用[J]. 中华医学杂志, 2015, 95(34): 2791-2795. [11] 雷鸣, 邓丽影, 刘昊. 脑梗死患者阻塞性睡眠呼吸紊乱与脑动脉粥样硬化风险的临床分析[J]. 中国老年学杂志, 2011, 31(12): 4769-4772. [12] ElHAGE R, JAWIEn J, RuDlInG M, et al. Reduced atherosclerosis in interleukin-18 deficient apolipoprotein E-knockout mice[J]. Cardiovasc Res, 2003, 59(1): 234-240. [13] COJOCARu E, TRAnDAfIRESCu M, lEOn M, et al. Immunohistochemical expression of anti-CD68 antibody in atherosclerotic plaque[J]. Rom J Morphol Embryol, 2012 , 53 (1): 61-66. [14] AnOGEIAnAKI A, AnGEluCCI D, CIAnCHETTI E, et al. Atherosclerosis: a classic inflammatory disease[J]. Int J Immunopathol Pharmacol, 2011, 11 (4): 817-825.