Abstract: Objective To investigate the effect of general anesthesia combined with epidural anesthesia in elderly patients with surgery. Methods 100 cases of elderly patients with surgery in our hospital from August to December 2015 were randomly divided into the observation group and the control group, the control group was given general anesthesia, the observation group was given epidural anesthesia, the hemodynamics and postoperative recovery time, recovery period, cognitive avoidance obstacle and security of two groups were compared. Results The results indicated that the blood pressure and heart rate at 3 min after intubation, surgical operation and extubation in the observation group were lower than that in the control group, wake up, extubation and response time were shorter than that in the control group, the difference was statistically significant(P<0.05). The rate of pain in observation group were lower than that in the control group, the MMSE score in 24 h and 12 h after operation were lower than that in control group, and the difference were statistically significant(P<0.05). The adverse reactions between the two groups were not statistically significant(χ²=0.796,P>0.05). Conclusion General anesthesia combined with epidural anesthesia can maintain the stability of vital signs, improve the awakening quality and reduce the incidence of postoperative cognitive impairment.

Key words: general anesthesia, epidural anesthesia, operation in the elderly, hemodynamics, cognition