Advances on the damage factors of sperm DNA

doi:10.3969/j.issn.1674-490X.2014.03.017

Abstract

Abstract: Human sperm DNA damage is one of the common causes of reducing male reproductive capacity. A number of factors can bring out the DNA strand breaks or make double-stranded DNA into single-stranded DNA. To a certain extent, some sperm with damaged DNA may escape from the sperm surveillance mechanism and transmit the damage to the offspring, which may give rise to the associated diseases such as abnormal embryonic development, early natural abortion, congenital anomalies and so on. This review assessses the damage factors of sperm DNA, which include ages, time of celibation, environment, freezing of sperm, oxidative stresse, minor element and the abnormal assembling of chromatin, which provides some basic information for elucidating the mechanism of DNA damage, prevention and treatment of male infertility as well as optimal spermatozoa selection in assisted reproductive technique.

Key words: sperm DNA damage, age, time of celibation, environment

CLC Number:

R698

GE Shaoqin,ZHAO Zhenghui,YIN Huiying,LIANG Qun,WANG Chuanchuan,DING Gaopeng,XU Zhenguo. Advances on the damage factors of sperm DNA[J]. Medical Reserch and Education, 2014, 31(3): 61-65.

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