doi:10.3969/j.issn.1674-490X.2019.03.005

Abstract

Abstract: Objective To investigate the correlation between cerebral microhemorrhage(CMBs)in patients with cerebral infarction(CI)and the markers of vascular endothelial injury: intercellular adhesion molecule-1(ICAM-1), endothelial nitric oxide synthase(eNOS)and soluble thrombokinin(sTM), and its clinical significance.Methods A total of 106 CI patients admitted to the Neurology Department of the Affiliated Hospital of Hebei University from July 2017 to June 2018 were collected.After craniocerebral SWI examined and confirmed no CMBs 37 cases(groupⅠ)and merge CMBs 69 cases(group II). Basic data and serum of patients in the two groups were collected, and the contents of ICAM-1, eNOS and sTM were quantitatively determined by ELISA to discuss the relationship between them and CMBs after CI.Results The levels of eNOS, ICAM-1 and sTM in groupⅡof patients were significantly higher than the levels of group Ⅰ. Three months later, group Ⅱ patients of cerebral infarction convalescence serum ICAM-1 and sTM level was still higher than the group of patients, for group I patients recovery of serum eNOS level higher than group Ⅱ.Conclusion The increased plasma ICAM-1, eNOS and sTM are closely related to CMBs after CI, and the changes in their contents have a certain predictive effect on the occurrence of CMBs.

Key words: cerebral infarction, cerebral microbleeds, soluble thrombokinin, endothelial nitric oxide synthase, intercellular adhesion molecule-1

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