Abstract: Objective To explore the practical value of case-based learning method in the teaching of medical genetics based on outcome-based education(OBE)concept. Methods “Chromosomal Diseases” teaching as an example was designed and implemented. 70 students from clinical medical specialty at Grade 2022 in our university were randomly divided as two groups: control group(n=35)and experimental group(n=35)in “Chaoxing” learning platform. Traditional lecture-based learning method was employed in control group, and case-based learning method based on OBE concept was carried out in experimental group. The differential analysis of all statistical data was performed using the SPSS 17.0 statistical software. Results The diversified teaching evaluation demonstrated that:(1)The total scores of chapter testing in experimental group and control group were respectively 81.71±5.90 and 71.77±5.19, and the difference was statistically significant(P<0.01).(2)The satisfaction with teaching in experimental group was higher than that in control group(P<0.05).(3)Considering the achievement of teaching goals, the much higher grades of multiple self-evaluation items in experimental group were scored than that of control group(P<0.05).(4)In the teaching evaluation of teaching supervision staff, experimental group were given higher marks(89.00±4.55)than that of control group(70.50±3.32), and the difference had statistical significance(P<0.01).(5)Rather more time in experimental group was spent learning teaching courseware and reference materials during the preview period, and review post-classes than that in control group(P<0.05, P<0.01). Conclusion Application of case-based learning method based on OBE concept fully mobilize students' initiative of self-learning, could markedly improve the teaching effects of “Chromosome disease”, and therefore provide a reference for learning other classes of genetic diseases.

Key words: outcome-based education, case-based learning, medical genetics, chromosomal diseases