Journal of Hebei Medical College for Continuing Education

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Medical Reserch and Education 2017, 34 (1): 1-6. DOI: 10.3969/j.issn.1674-490X.2017.01.001

Abstract （364）

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Objective To investigate SLC5A8 gene’s transcription level of mRNA and its methylation status in colorectal cancer.Methods Real-time fluorescence quantitative PCR and methylation specific PCR method(MSP)were used to detect the transcription level of SLC5A8 gene’s mRNA and the methylation level of SLC5A8 gene in 40 cases of colorectal cancer tissues and adjacent tissues.Results The rate of transcription level of SLC5A8 gene’s mRNA in colorectal cancer rate was significantly lower than that in tumor adjacent tissues(χ²=16.241,P<0.05),the positive rate of SLC5A8 gene methylation in colorectal cancer tissues was significantly higher than that in adjacent tissues(χ²=32.237,P<0.05),the transcription level of this gene’s mRNA was negatively correlated with its methylation status.The correlation coefficient was 0.875.Conclusion SLC5A8 gene methylation can significantly reduce the expression of the gene,which may be associated with the occurrence of colorectal cancer.

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Medical Reserch and Education 2017, 34 (1): 7-9. DOI: 10.3969/j.issn.1674-490X.2017.01.002

Abstract （445）

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Objective To study characteristic expression of adrenal medullary lipoma(AML)in the MSCTand improve diagnostic accuracy and diagnostic level of AML of the MSCT.Methods 12 cases of adrenal medullary lipoma were confirmed by surgical in the Traditional Chinese Medicine Hospital of Puyang form 2012 to 2015,and AML’s expression characteristics in the MSCT were analyzed retrospectively.Results Among 12 cases of adrenal medullary lipoma,most of the lumps shape indicated round or class round,and the boundary was clear.Off them 9 cases had the majority of adipose tissue,3 cases with a little adipose tissue,2 cases had calcification. The CT enhanced examination showed that the solid tumor component and septa and involucrum were mild enhancement,and the adipose tissue was no enhancement.Conclusion The MSCT has great diagnostic value in the diagnosis and antidiastole of adrenal medullary lipoma.

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Medical Reserch and Education 2017, 34 (1): 10-14. DOI: 10.3969/j.issn.1674-490X.2017.01.003

Abstract （371）

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Objective To explore the predictive value of TCM four diagnostic information related to HMG induced ovulation.Methods During the period from January 2009 to March 2012,250 cases of infertility were treated with induced ovulation,according to the curative effect were divided into failure group(180 cases)and the successful group(70 cases).The two groups of statistical analysis were carried out after collecting the information of four diagnostic methods,such as symptoms,tongue and pulse,in the form of questionnaire survey.Results The two groups four diagnostic information had significant statistical difference.The multivariate regression analysis showed that thirsty and preference for cold drinks,soreness and weakness of the lumbar region,rapid pulse and massive pulse had negative correlation with curative effect,while thready pulse and thin-white-fur had positive correlation with it.Conclusion There is obvious correlation between the four diagnosis information and the ovulation induction effect,which has a predictive value for the effect of ovulation induction.

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Medical Reserch and Education 2017, 34 (1): 15-17. DOI: 10.3969/j.issn.1674-490X.2017.01.004

Abstract （570）

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Objective To investigate the clinical effects of acupuncture Shuigou,GV26 as bird-pecking strong stimulation in treating acute lumbar sprain.Methods 60 cases with acute lumbar sprain were randomly divided into two groups.30 cases inthe observation group were adopted acupuncture Shuigou,GV26 as bird-pecking reduction.30 cases in the control group adopted acupuncture Shuigou,GV26 with the uniform reinforcing-reducing method.After the treatment,the unified standard of efficacy was used.Results The general effective rate of observation group was 93.33%,while the control group was 63.33%.The results indicated that there was a statistical significance between these two groups(P<0.05).Conclusion Acupuncture Shuigou,GV26 bird-pecking stimulation can improve remarkably the clinical efficacy in treating acute lumbar sprain.

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Medical Reserch and Education 2017, 34 (1): 18-21. DOI: 10.3969/j.issn.1674-490X.2017.01.005

Abstract （382）

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Objective To understand the poliomyelitis antibody level of healthy population in Baoding city from 2011 to 2015 and evaluate immune effect, so as to provide scientific basis for the control and prevention.Methods The poliomyelitis antibody level of healthy people was detected by neutralization test of the micro cells from each country of Baoding city(contain 23 counties).Results The neutralizing antibody positive rates of I,II,III viruses were 99.83%,99.83% and 100%, respectively, and the geometric mean titer(GMT)were 1︰157.95, 1︰154.34, 1︰149.78.There were no statistical differences forⅠ, Ⅱ, and Ⅲ polio antibody GMT between different age groups and different counties or districts.Conclusion The immunization cold-chain system of Baoding city is being run in good condition and effect of polio vaccine immunization is remarkable.Importantly, a protective barrier had been built against polio in healthy people in Baoding city.

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Medical Reserch and Education 2017, 34 (1): 22-25. DOI: 10.3969/j.issn.1674-490X.2017.01.006

Abstract （439）

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Objective To investigate the efficacy of nursing care applying to complex pilon fracture patients treated with damage control operation.Mothods Fifty six patients underwent with damage control orthopeadics(two stages).Data were collected from march 2011 to march 2015.Results The average postoperative hospitalization time was fourteen(14±1.6)d.No complication happened,such as infection,skin necrosis,all patients were discharged successfully and the functions were satisfactory through follow up for 4 to 6 months.Conclusion Two stages nursing care applying to complex pilon fracture can be successful coverage,which is quite effective in treating these patients.

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Medical Reserch and Education 2017, 34 (1): 26-32. DOI: 10.3969/j.issn.1674-490X.2017.01.007

Abstract （607）

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Myriads of studies indicate that sperm with severe head morphological abnormalities is closely associated with low fertilization,implantation and pregnancy rate.Selecting high quality sperm used for ART(assisted reproductive techniques)is an effective way to improve the clinic outcome.A normal sperm selected under a optical microscope with low magnification(×200)could contain some ultrastructural defects,which may result in fertilization failure or arrest of embryonic development after ICSI(Intracytoplasmic sperm injection).However,intracytoplasmic morphologically selected sperm injection(IMSI)shows the perfect match between ICSI and MSOME(Motile sperm organelles morphology examination),which can evaluate the quality of sperm morphology and cherry-pick sperm with none or less vacuole for microinjection to increase the rates of fertilization,implantation and pregnancy,as well as decrease the abortion rate.The examination is performed using a differential interference contrast microscopy and digital imaging technologyto achieve a magnification up to 6 600×.This review mainly focus on the development history of IMSI techniques,its application in optimal selection of sperm and analysis of clinical outcomes,which will provide some theoretical directions to its application popularization and further development.

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Medical Reserch and Education 2017, 34 (1): 33-38. DOI: 10.3969/j.issn.1674-490X.2017.01.006

Abstract （316）

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Gastric cancer is a common cancer,with high morbidity and mortality.Despite there are a lot of research on the pathogenesis of gastric cancer,but the exact mechanism is still unclear.Nuclear factor kappa B(NF-κB)exists widely in cells which are significantly related to differentiation,proliferation,apoptosis,immune response and stress response.In addition to the NF-κB signaling pathway disorders in gastric cancer in the origin and development,invasion and metastasis,therapy and prevention are involved.We summarize recent progress in understanding the role of the NF-κB pathway in gastric cancer.

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Medical Reserch and Education 2017, 34 (1): 39-43. DOI: 10.3969/j.issn.1674-490X.2017.01.009

Abstract （525）

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Qualitative research is a research method to describe life experience and give its meaning,and it is widely used in nursing field.Qualitative research reporters about nursing of coronary heart disease are reviewed.which includes study objects,methods,and study angles and results of these references.The patients’ experience of physiology,experience of psychosocial and necessity are explored in order to provide references for effective interventions and other related researches in the future.

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Medical Reserch and Education 2017, 34 (1): 44-48. DOI: 10.3969/j.issn.1674-490X.2017.01.010

Abstract （396）

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The morbidity and mortality of cardiovascular disease(CVD)have been higher and higher,which can be prevented through reducing and eliminating some risk factors.Therefore,primary prevention should be carried out to control CVD.This paper focuses on relevant information about primary prevention of CVD,in order to provide strategy for the effective primary prevention of CVD.

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Medical Reserch and Education 2017, 34 (1): 49-55. DOI: 10.3969/j.issn.1674-490X.2017.01.011

Abstract （414）

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Non-alcoholic fatty liver disease(NAFLD)is one of the most common chronic liver diseases.Although the incidence rate of NAFLD is rising rapidly in our country,effective clinical treatment is still lacking.Due to the close anatomical and functional relationship between the gut and the liver,emerging evidence suggests an important role of gut microbiota in the initiation and progression of NAFLD.Altered gut microbiota due to environmental factors can lead to liver damage.Results of animal studies strongly support the protective effect of probiotics against NAFLD.Currently,there is only a small number of randomized controlled clinical trials evaluating the effectiveness of probiotics on NAFLD treatment;nonetheless,findings show intake of probiotics can improve symptoms of the disease.More multi-centre large-scale randomized controlled trials are needed in order to provide evidence for clinical application of probiotics.

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Medical Reserch and Education 2017, 34 (1): 56-61. DOI: 10.3969/j.issn.1674-490X.2017.01.012

Abstract （379）

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Objective To explore the model of problem-based learning(PBL)applied in teaching theoretical and experimental courses in hygienic toxicology and its effects in teaching.Besides,the effects of PBL model on the development of undergraduate’s other abilities in preventive medicine were evaluated.Methods Sixty undergraduates majoring in preventive medicine from two classes in China Medical University were selected as subjects in the study.The two classes were randomly divided into PBL and traditional teaching groups respectively.The PBL effect and influence of PBL on the development of undergraduate’s other abilities were investigated by the means of course examination and questionnaire.Results The average score,excellent ratio of course examination and ratio of satisfaction to teaching model in PBL teaching group were significantly higher than those in traditional teaching group.The rates of approval about “broadening of horizon,deepening of knowledge memory,increase of learning interest,improvement of self learning and thinking ability,enhancement of expression ability,improvement of innovation ability,enhancement of ability in analysis and treatment of problem and increase of ability in cooperation and communication ” in PBL teaching group were significantly higher than that in traditional teaching group.Conclusion The model of PBL could improve quality and result of teaching in hygienic toxicology effectively,help to broaden knowledge,deepen memory of knowledge,increase interest of learning,and thus promote the development of undergraduate’s other abilities in preventive medicine.

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Medical Reserch and Education 2017, 34 (1): 62-66. DOI: 10.3969/j.issn.1674-490X.2017.01.013

Abstract （508）

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Creative thinking is the core of the medical students' innovative activities,is also the focus of the current medical education reform in China.On the basis of knowing the demands,characteristics and psychological quality in cognitive medical students' innovative thinking,we should dare to doubt,criticize,strengthen the system knowledge,and change inherent mind-set for training creative thinking in medical students.All these measures can strengthen innovative thinking training of medical students,improve their innovative ability,and make them be good at learning,thinking,exploring.

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Medical Reserch and Education 2017, 34 (1): 67-71. DOI: 10.3969/j.issn.1674-490X.2017.01.014

Abstract （330）

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Objective To explore the application effects of the Case based learning(CBL)teaching method combined with Lecture-based learning(LBL)in teaching blood gas analysis(ABG)with the conventional teaching method as the control. Methods 72 interns of the undergraduate were randomly divided into 2 groups: conventional LBL teaching group(group LBL)and CBL+LBL teaching group(group CBL+LBL)to evaluate the teaching impact of the two teaching methods. Results The CBL+LBL teaching method was more advantageous than the conventional LBL teaching method by the objective scores of the examinations,the subjective self-evaluation of the students and the self-assessment of the teachers. Conclusion The advantages of the good integrity and the combination of the practice and theory in the CBL combined with LBL teaching leave the clinicians more room to play and make the students comprehend and apply better.

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Medical Reserch and Education 2017, 34 (1): 72-77. DOI: 10.3969/j.issn.1674-490X.2017.01.015

Abstract （471）

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Objective To investigate the teaching situations and demands on pharmacology in vocational colleges students and provide a scientific basis for further course reform.Methods The teaching programs from 25 vocational colleges were investigated by interviews,the demands of specialty teachers and the staffs from 7 rehabilitation departments on pharmacology were examined by applying questionnaire.Results Professional core courses were more consistent between intercollegiate,however,basic medicine had remarkable differences,especially in pharmacology teaching aspects,and the teaching contents and time allocations were lack of basis.Specialty teachers and the staffs had different demands for knowledge of pharmacology but had the same demands on the same points.Conclusion Pharmacology courses is necessary in vocational rehabilitation.Curriculum reform of basic medicine should first refine on the teaching contents based on the needs analysis,embodying professional applicability and pertinence to improve teaching quality.

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Medical Reserch and Education 2017, 34 (1): 78-80. DOI: 10.3969/j.issn.1674-490X.2017.01.016

Abstract （295）

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Medical Reserch and Education 2017, 34 (2): 1-10.

Abstract （297）

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